Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications.
Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications.
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DOI：
10.1371/journal.pbio.3002022
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发表时间：
2023-02
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
--
作者：
过去20年的研究已经阐明了与疾病相关的新的先天免疫传感和细胞死亡途径。这些途径及其串扰和功能冗余的未来分子表征将有助于治疗策略的发展。过去20年的研究揭示了几种新的先天免疫传感和细胞死亡途径与疾病相关。这一观点回顾了这些发现的影响，并展望了它们未来的治疗潜力。
The past 20 years of research has elucidated new innate immune sensing and cell death pathways with disease relevance. Future molecular characterization of these pathways and their crosstalk and functional redundancies will aid in development of therapeutic strategies. The past 20 years of research has revealed several new innate immune sensing and cell death pathways with disease relevance. This Perspective looks back over the impact these discoveries have had and forwards toward their future therapeutic potential.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
16
作者：
Martinon, F;Burns, K;Tschopp, J
通讯作者：
Tschopp, J
影响因子：
64.5
作者：
Karki R;Sharma BR;Tuladhar S;Williams EP;Zalduondo L;Samir P;Zheng M;Sundaram B;Banoth B;Malireddi RKS;Schreiner P;Neale G;Vogel P;Webby R;Jonsson CB;Kanneganti TD
通讯作者：
Kanneganti TD
影响因子：
14.8
作者：
Degterev, A;Huang, ZH;Yuan, JY
通讯作者：
Yuan, JY
影响因子：
12.4
作者：
Galluzzi L;Vitale I;Aaronson SA;Abrams JM;Adam D;Agostinis P;Alnemri ES;Altucci L;Amelio I;Andrews DW;Annicchiarico-Petruzzelli M;Antonov AV;Arama E;Baehrecke EH;Barlev NA;Bazan NG;Bernassola F;Bertrand MJM;Bianchi K;Blagosklonny MV;Blomgren K;Borner C;Boya P;Brenner C;Campanella M;Candi E;Carmona-Gutierrez D;Cecconi F;Chan FK;Chandel NS;Cheng EH;Chipuk JE;Cidlowski JA;Ciechanover A;Cohen GM;Conrad M;Cubillos-Ruiz JR;Czabotar PE;D'Angiolella V;Dawson TM;Dawson VL;De Laurenzi V;De Maria R;Debatin KM;DeBerardinis RJ;Deshmukh M;Di Daniele N;Di Virgilio F;Dixit VM;Dixon SJ;Duckett CS;Dynlacht BD;El-Deiry WS;Elrod JW;Fimia GM;Fulda S;García-Sáez AJ;Garg AD;Garrido C;Gavathiotis E;Golstein P;Gottlieb E;Green DR;Greene LA;Gronemeyer H;Gross A;Hajnoczky G;Hardwick JM;Harris IS;Hengartner MO;Hetz C;Ichijo H;Jäättelä M;Joseph B;Jost PJ;Juin PP;Kaiser WJ;Karin M;Kaufmann T;Kepp O;Kimchi A;Kitsis RN;Klionsky DJ;Knight RA;Kumar S;Lee SW;Lemasters JJ;Levine B;Linkermann A;Lipton SA;Lockshin RA;López-Otín C;Lowe SW;Luedde T;Lugli E;MacFarlane M;Madeo F;Malewicz M;Malorni W;Manic G;Marine JC;Martin SJ;Martinou JC;Medema JP;Mehlen P;Meier P;Melino S;Miao EA;Molkentin JD;Moll UM;Muñoz-Pinedo C;Nagata S;Nuñez G;Oberst A;Oren M;Overholtzer M;Pagano M;Panaretakis T;Pasparakis M;Penninger JM;Pereira DM;Pervaiz S;Peter ME;Piacentini M;Pinton P;Prehn JHM;Puthalakath H;Rabinovich GA;Rehm M;Rizzuto R;Rodrigues CMP;Rubinsztein DC;Rudel T;Ryan KM;Sayan E;Scorrano L;Shao F;Shi Y;Silke J;Simon HU;Sistigu A;Stockwell BR;Strasser A;Szabadkai G;Tait SWG;Tang D;Tavernarakis N;Thorburn A;Tsujimoto Y;Turk B;Vanden Berghe T;Vandenabeele P;Vander Heiden MG;Villunger A;Virgin HW;Vousden KH;Vucic D;Wagner EF;Walczak H;Wallach D;Wang Y;Wells JA;Wood W;Yuan J;Zakeri Z;Zhivotovsky B;Zitvogel L;Melino G;Kroemer G
通讯作者：
Kroemer G