Endocannabinoid receptors: CNS localization of the CB₁ cannabinoid receptor.
Endocannabinoid receptors: CNS localization of the CB₁ cannabinoid receptor.
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内源性大麻素受体：CB₁ 大麻素受体的中枢神经系统定位。
DOI：
10.1007/978-3-540-88955-7_3
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发表时间：
2009
影响因子：
--
通讯作者：
I. Katona
中科院分区：
文献类型：
--
作者：
I. Katona
植物代谢途径的进化创造了分散捕食者注意力的化合物，医学的历史找到了疾病的治疗方法，通常有一个共同的逻辑。一个有吸引力的例子来说明这背后的理由是大麻植物，这是利用其广泛的治疗效果了几千年，但历史上的“处方”强调其分散注意力的行为副作用，如果滥用。本章旨在解释theCannabisplant的广泛的药理学和行为特征，指出CB 1大麻素受体，其主要的分子靶点，在整个神经系统中无处不在的解剖分布。然而，在其丰富的区域和细胞定位，CB 1受体和参与其主要内源性配体，2-花生四烯酸甘油（2-AG）的代谢酶的亚细胞排列相反，显着极化的神经元表面在成人大脑。虽然仍有一些未解决的问题，已知的拼图块勾勒出一幅图片，其中2-AG的生物合成机制积累在神经元的体树突区室，而它的受体和降解酶都发现在轴突终末。这种分子结构表明，内源性大麻素信号传导的主要生理作用是突触传递的逆行调节，本章的目的是总结令人信服的证据，它是一个古老的和基本的组成部分，几种不同类型的突触在整个神经系统。
The evolution of plant metabolic pathways to invent compounds which distract predators, and the history of medicine to find treatments for diseases, often share a common logic. An attractive example to illustrate the rationale behind this is theCannabis sativaplant, which was exploited for its widespread therapeutic effects for several thousand years, but historical “prescriptions” highlighted its distractive behavioral side-effects if abused. This chapter aims to explain the characteristically wide pharmacological and behavioral profile of theCannabisplant by pointing to the ubiquitous anatomical distribution of CB1cannabinoid receptors, its predominant molecular target, throughout the nervous system. However, in contrast to their abundant regional and cellular localization, the subcellular arrangement of CB1receptors and the enzymes involved in the metabolism of its main endogenous ligand, 2-arachidonoylglycerol (2-AG), are strikingly polarized on the neuronal surface in the adult brain. Though there are still several unresolved issues, the known pieces of the puzzle outline a picture in which the biosynthetic machinery for 2-AG is accumulated in the somatodendritic compartment of neurons, whereas its receptor and degrading enzyme are both found on axon terminals. This molecular architecture suggests that a main physiological role of endocannabinoid signaling is the retrograde regulation of synaptic transmission, and the present chapter aims to summarize compelling evidence that it is an ancient and fundamental component of several distinct types of synapses throughout the nervous system.
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影响因子：
56.9
作者：
Berghuis, Paul;Rajnicek, Ann M.;Harkany, Tibor
通讯作者：
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影响因子：
4.7
作者：
Matyas, Ferenc;Urban, Gabriella M.;Katona, Istvan
通讯作者：
Katona, Istvan
影响因子：
4.8
作者：
Okamoto, Y;Morishita, J;Ueda, N
通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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