Maturational trajectories of non-rapid eye movement slow wave activity and odds ratio product in a population-based sample of youth.
Maturational trajectories of non-rapid eye movement slow wave activity and odds ratio product in a population-based sample of youth.
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DOI：
10.1016/j.sleep.2021.05.002
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发表时间：
2021-07
期刊：
影响因子：
4.8
通讯作者：
Fernandez-Mendoza J
中科院分区：
文献类型：
--
作者：
Ricci A;He F;Fang J;Calhoun SL;Vgontzas AN;Liao D;Younes M;Bixler EO;Fernandez-Mendoza J
睡眠脑电图 (EEG) 反映了大脑的成熟，即整个青春期非快速眼动 (NREM) 慢波活动 (SWA) 的下降以及睡眠深度的相关下降。然而，这一轨迹及其性别和青春期差异在基于人群的样本中缺乏复制。我们测试了 SWA (0.4-4 Hz) 功率和比值比积 (ORP)（睡眠深度的标准化测量）与年龄相关的变化。我们分析了 572 名 6-21 岁受试者（48% 女性，26% 少数族裔）和 332 名 5-12 岁受试者的睡眠脑电图，并在 12-22 岁随访。多变量调整分析测试了与年龄相关的 SWA 和 ORP 横截面和纵向轨迹。 SWA 从 6 岁到 10 岁保持稳定，在 11 岁到 17 岁之间下降，并在 18 岁到 21 岁之间趋于稳定（p-cubic<0.001）；女性在 13 岁时的纵向下降比男性高 23%，而男性在 14 岁时经历了更陡峭的斜率，到 19 岁时纵向下降比男性高 21%。 14 岁时，较成熟的青少年（75% 为女性）的 SWA 纵向下降幅度比较不成熟的青少年更大。 ORP 显示出与年龄相关的增加轨迹（p 线性<0.001），没有性别或青春期差异。我们提供了从儿童期到青春期过渡过程中 SWA 的成熟衰退以及性别和青春期差异的人口水平证据，同时引入 ORP 作为青年时期的一种新指标。与之前的研究一起，观察到的不同轨迹表明，SWA 中与年龄相关的变化反映了该发育时期的大脑成熟和局部/突触过程，而 ORP 的变化可能反映了 NREM 睡眠深度的全局/状态控制。
Brain maturation is reflected in the sleep electroencephalogram (EEG) by a decline in non-rapid eye movement (NREM) slow wave activity (SWA) throughout adolescence and a related decrease in sleep depth. However, this trajectory and its sex and pubertal differences lack replication in population-based samples. We tested age-related changes in SWA (0.4-4 Hz) power and odds ratio product (ORP), a standardized measure of sleep depth. We analyzed the sleep EEG of 572 subjects aged 6-21y (48% female, 26% racial/ethnic minority) and 332 subjects 5-12y followed-up at 12-22y. Multivariable-adjusted analyses tested age-related cross-sectional and longitudinal trajectories of SWA and ORP. SWA remained stable from age 6 to 10, decreased between ages 11 and 17, and plateaued from age 18 to 21 (p-cubic<0.001); females showed a longitudinal decline 23% greater than males by 13y, while males experienced a steeper slope after 14y and their longitudinal decline was 21% greater by 19y. More mature adolescents (75% female) experienced a greater longitudinal decline in SWA than less mature adolescents by 14y. ORP showed an age-related increasing trajectory (p-linear<0.001) with no sex or pubertal differences. We provide population-level evidence for the maturational decline and sex and pubertal differences in SWA in the transition from childhood to adolescence, while introducing ORP as a novel metric in youth. Along with previous studies, the distinct trajectories observed suggest that age-related changes in SWA reflect brain maturation and local/synaptic processes during this developmental period, while those of ORP may reflect global/state control of NREM sleep depth.
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影响因子：
4.8
作者：
Calhoun, Susan L.;Fernandez-Mendoza, Julio;Vgontzas, Alexandros N.;Liao, Duanping;Bixler, Edward O.
通讯作者：
Bixler, Edward O.
DOI：
10.1073/pnas.1120860109
发表时间：
2012-04-10
影响因子：
11.1
作者：
Campbell, Ian G.;Grimm, Kevin J.;Feinberg, Irwin
通讯作者：
Feinberg, Irwin
影响因子：
4.3
作者：
Gova-Sagiv, Maya;Nir, Yuval
通讯作者：
Nir, Yuval
影响因子：
4.8
作者：
Danisi, Jacqueline M.;Fernandez-Mendoza, Julio;Bixler, Edward O.
通讯作者：
Bixler, Edward O.
DOI：
10.1016/j.bbi.2016.12.026
发表时间：
2017-03
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Fernandez-Mendoza J;Baker JH;Vgontzas AN;Gaines J;Liao D;Bixler EO
通讯作者：
Bixler EO