Nutrition and metabolism--sphingolipids and branched chain amino acids: indicators and effectors of adipose tissue function and diabetes risk.
Nutrition and metabolism--sphingolipids and branched chain amino acids: indicators and effectors of adipose tissue function and diabetes risk.
复制标题
营养和代谢——鞘脂和支链氨基酸：脂肪组织功能和糖尿病风险的指标和效应器。
DOI：
10.1097/mol.0b013e32834d1716
复制
发表时间：
2011
影响因子：
4.4
通讯作者：
Ballantyne,ChristieM
中科院分区：
文献类型：
--
作者：
Belalcazar,LMaria;Ballantyne,ChristieM
Recent findings related to alterations in the metabolism of sphingolipids [1] and branched chain amino acids (BCAAs)[2] bring back to our attention the importance of adipose tissue in the development of insulin resistance, type 2 diabetes and the chronic inflammatory and prothrombotic state characteristic of these conditions [3, 4]. A nutrient supply that exceeds the tissue’s oxidative or storage capacity alters intracellular signaling and leads to the development of insulin resistance and inflammation.Sphingolipids are bioactive lipids produced de novo, of which ceramide and its breakdown product, sphingosine-1 phosphate (S1P) are of great metabolic interest [5]. Sphingolipid synthesis partly depends on saturated fatty acid availability, particularly palmitate [6]. The accumulation of ceramide is associated with insulin resistance, apoptosis and the development of hepatic steatosis, cardiomyopathy and B-cell insufficiency [1, 6, 7].
影响因子：
29
作者：
Yecies JL;Zhang HH;Menon S;Liu S;Yecies D;Lipovsky AI;Gorgun C;Kwiatkowski DJ;Hotamisligil GS;Lee CH;Manning BD
通讯作者：
Manning BD
环丝氨酸和苏式二氢鞘氨醇抑制 TNF-α 诱导的细胞毒性：神经酰胺从头合成在 TNF-α 信号转导中重要性的证据。
DOI：
--
发表时间：
2003
期刊：
Biochimica et Biophysica Acta
影响因子：
--
作者：
Sybille G. E. Meyer;H. de Groot
通讯作者：
H. de Groot
影响因子：
15.9
作者：
Holland, William L.;Bikman, Benjamin T.;Summers, Scott A.
通讯作者：
Summers, Scott A.