Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy.
Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy.
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DOI：
10.1186/1757-2215-6-95
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发表时间：
2013-12-27
影响因子：
4
通讯作者：
Kucia M
中科院分区：
文献类型：
--
作者：
Ratajczak MZ;Jadczyk T;Schneider G;Kakar SS;Kucia M
众所周知，化疗和放疗的副作用主要与毒性和重要器官功能受损有关；然而，令人惊讶的是，这些疗法在各种组织和器官中诱导几种促转移因子的表达，从而创造一个促转移微环境，这一点仍然没有得到广泛承认。在这篇综述中，我们支持这样一个新概念，即各种器官的毒性损伤导致“旁观者”组织中几种因子的上调，如趋化因子、生长因子、警报器和生物活性磷脂，这些因子吸引循环正常干细胞进行再生，但不幸的是，它们也为在初始治疗中存活下来的癌细胞提供趋化信号。我们认为这一机制在癌细胞向骨、肺、肝等器官转移的过程中发挥了重要作用，这些器官对化疗药物和电离辐射非常敏感。这个问题表明，需要开发有效的抗转移药物，这些药物将与标准疗法联合或遵循，以防止治疗诱导肿瘤细胞扩散的可能性。
There are well-known side effects of chemotherapy and radiotherapy that are mainly related to the toxicity and impaired function of vital organs; however, the induction by these therapies of expression of several pro-metastatic factors in various tissues and organs that in toto create a pro-metastatic microenvironment is still, surprisingly, not widely acknowledged. In this review, we support the novel concept that toxic damage in various organs leads to upregulation in “bystander” tissues of several factors such as chemokines, growth factors, alarmines, and bioactive phosphosphingolipids, which attract circulating normal stem cells for regeneration but unfortunately also provide chemotactic signals to cancer cells that survived the initial treatment. We propose that this mechanism plays an important role in the metastasis of cancer cells to organs such as bones, lungs, and liver, which are highly susceptible to chemotherapeutic agents as well as ionizing irradiation. This problem indicates the need to develop efficient anti-metastatic drugs that will work in combination with, or follow, standard therapies in order to prevent the possibility of therapy-induced spread of tumor cells.
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影响因子：
1.2
作者：
Brouard, Nathalie;Driessen, Rebecca;Simmons, Paul J.
通讯作者：
Simmons, Paul J.
影响因子：
50.3
作者：
Hiratsuka, S;Nakamura, K;Shibuya, M
通讯作者：
Shibuya, M
影响因子：
82.9
作者：
Ceradini, DJ;Kulkarni, AR;Gurtner, GC
通讯作者：
Gurtner, GC
影响因子：
32.4
作者：
Ara, T;Tokoyoda, K;Nagasawa, T
通讯作者：
Nagasawa, T
影响因子：
--
作者：
Heffernan-Stroud LA;Obeid LM
通讯作者：
Obeid LM