Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer.
Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer.
复制标题
DOI：
10.1186/1471-2407-11-64
复制
发表时间：
2011-02-10
期刊：
影响因子：
3.8
通讯作者：
Nagawa H
中科院分区：
文献类型：
--
作者：
Kitayama J;Yasuda K;Kawai K;Sunami E;Nagawa H
尽管术前放疗（RT）被广泛用作新辅助治疗中局部晚期直肠癌（RC）的初始治疗，但决定临床反应的因素尚未得到充分定义。为了寻找可能与放射敏感性相关的其他因素，我们评估了循环血细胞计数与RT效应之间的关系。回顾性分析了179例晚期RC患者放疗前后血红蛋白（Hb）水平、白色细胞（WBC）、血小板及WBC亚群计数，并与其他临床病理因素一起探讨其与完全缓解（CR）率的关系。15例CR患者放疗前白细胞中淋巴细胞比例明显高于非CR患者。淋巴细胞百分比高的患者（25.7%）的预后较好。相反，CR病例中中性粒细胞的比例降低。多因素分析显示，淋巴细胞比率与CR独立相关，CR患者淋巴细胞比率有维持在较高水平的趋势。在RC患者中，外周血淋巴细胞对RT反应的CR率有显着影响。淋巴细胞介导的免疫反应被认为对RC放射治疗的临床反应有积极作用。
Although preoperative radiotherapy (RT) is widely used as the initial treatment for locally advanced rectal cancer (RC) in the neoadjuvant setting, factors determining clinical response have not been adequately defined. In order to find other factors possibly related with radiosensitivity, we evaluated the relationships between circulating blood cell counts and RT effects. In 179 cases with advanced RC, we retrospectively examined hemoglobin (Hb) levels and counts of white blood cells (WBC), platelets and WBC subsets before and after RT and investigated their associations with the complete response (CR) rate together with other clinicopathological factors. The ratio of lymphocytes in WBC taken before RT was significantly greater in 15 CR cases as compared with those in non-CR cases. Patients with high lymphocyte percentages (25.7%) showed better outcome than the counterparts. Conversely, the ratio of neutrophiles was reduced in CR cases. The lymphocyte ratio showed an independent association with CR with multivariate analysis, and tended to be maintained at relatively high levels in CR cases. In RC patients, peripheral blood lymphocytes have a significant impact on the CR rate in response to RT. Lymphocyte-mediated immune reactions are supposed to have positive roles on clinical response in radiotherapy for RC.
登录
查看更多内容
影响因子：
158.5
作者：
Sauer, R;Becker, H;Raab, R
通讯作者：
Raab, R
影响因子：
45.3
作者：
Molling, Johan W.;Langius, Jacqueline A. E.;van den Eertwegh, Alfons J. M.
通讯作者：
van den Eertwegh, Alfons J. M.
影响因子：
11.5
作者：
Kuss, I;Hathaway, B;Whiteside, TL
通讯作者：
Whiteside, TL
影响因子：
11.2
作者：
Rodriguez PC;Ernstoff MS;Hernandez C;Atkins M;Zabaleta J;Sierra R;Ochoa AC
通讯作者：
Ochoa AC
DOI：
10.1016/j.ijrobp.2008.11.027
发表时间：
2009-11-01
影响因子：
7
作者：
Park, Hee Chul;Janjan, Nora A.;Mendoza, Tito R.;Lin, Edward H.;Vadhan-Raj, Saroj;Hundal, Mandeep;Zhang, Yiqun;Delclos, Marc E.;Crane, Christopher H.;Das, Prajnan;Wang, Xin Shelley;Cleeland, Charles S.;Krishnan, Sunil
通讯作者：
Krishnan, Sunil