Perinatal bile acid metabolism: analysis of urinary unsaturated ketonic bile acids in preterm and full‐term infants
Perinatal bile acid metabolism: analysis of urinary unsaturated ketonic bile acids in preterm and full‐term infants
复制标题
围产期胆汁酸代谢：早产儿和足月儿尿不饱和酮胆汁酸分析
作者：
K. Maeda;A. Kimura;Y. Yamato;T. Matsuishi
目的：比较早产儿和足月儿尿中不饱和酮胆汁酸的浓度。方法：采用气相色谱-质谱法测定尿液中不饱和酮胆汁酸。结果：早产儿(胎龄<29周)尿总胆汁酸浓度高于早产儿晚期(胎龄30~37周)和足月儿(胎龄38~41周)。足月婴儿尿中7a，12a-二羟基-3-氧代-4-胆烯酸和7a-羟基-3-氧代-4-胆烯酸占总胆汁酸的比例(20.2±14.1%)明显高于早产儿(8.9±8.1%；p<；0.05)。不饱和胆汁酸(3β-羟基-Δ，5-胆汁酸)占总胆汁酸的百分比，组间差异无统计学意义。
Aim: To compare urinary concentrations of unsaturated ketonic bile acids in preterm and full‐term infants. Methods: Urinary unsaturated ketonic bile acids were determined using gas chromatographymass spectrometry. Results: Urinary concentrations of total bile acids in early preterm infants (of less than 29 wk gestational age) exceeded concentrations in late preterm (between 30 and 37 wk) and full‐term infants (between 38 and 41 wk; p < 0.01). The percentage of ketonic bile acids (7a, 12a‐dihydroxy‐3‐oxo‐4‐cholenoic acid and 7a‐hydroxy‐3‐oxo‐4‐cholenoic acid) among total urinary bile acids in full‐term infants (20.2 ± 14.1%) was higher than that in early preterm infants (8.9 ± 8.1%; p < 0.05). The percentage of unsaturated bile acids (3β‐hydroxy‐Δ5‐bile acids) among total bile acids in urine did not differ greatly between groups.
影响因子：
6.5
作者：
W. Duane;N. Javitt
通讯作者：
W. Duane;N. Javitt
影响因子：
29.4
作者：
F. Suchy;W. Balistreri;J. Heubi;J. Searcy;R. Levin
通讯作者：
F. Suchy;W. Balistreri;J. Heubi;J. Searcy;R. Levin
影响因子：
15.9
作者：
SETCHELL, KDR;SUCHY, FJ;BALISTRERI, WF
通讯作者：
BALISTRERI, WF