Motor network plasticity and low-frequency oscillations abnormalities in patients with brain gliomas: a functional MRI study.
Motor network plasticity and low-frequency oscillations abnormalities in patients with brain gliomas: a functional MRI study.
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脑胶质瘤患者运动网络可塑性和低频振荡异常：功能性 MRI 研究
DOI：
10.1371/journal.pone.0096850
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Lin P
中科院分区：
文献类型：
--
作者：
Niu C;Zhang M;Min Z;Rana N;Zhang Q;Liu X;Li M;Lin P
大脑的可塑性通常与缓慢生长的肿瘤形成过程有关，肿瘤的形成重塑了神经组织，优化了大脑网络功能。在这项研究中，我们的目的是调查位于运动区或运动区附近的缓慢生长的脑肿瘤患者的运动功能可塑性是否会出现缺陷，但这些患者没有运动神经缺陷。我们使用静息状态功能磁共振成像探测了15例经组织病理证实的脑胶质瘤患者和15例年龄匹配的健康对照的运动网络。所有受试者都完成了一项运动任务，以帮助识别双侧初级运动皮质(PMC)和辅助运动区(SMA)中的个体运动活动。然后使用三种不同频率的基于频率的分析来研究低频振荡功率谱密度(PSD)的可能变化。对于每一组，确定每个大脑区域的平均PSD，并执行非参数检验来确定两组之间的功率差异。与对照组相比，患者左侧和右侧PMC之间的大脑半球间功能连接性显著降低(P<；0.05)。我们还发现，与对照组相比，患者在三个关键运动区的三个频段(低频段：0.01-0.02赫兹；中频段：0.02-0.06赫兹；高频段：0.06-0.1赫兹)PSD显著降低。这些发现表明，在无症状的脑肿瘤患者中，位于能言区的大脑半球之间的联系可能更容易受到攻击。两种方法的比较表明，功率谱分析比功能连通性分析更敏感地识别由生长缓慢的肿瘤引起的运动功能可塑性潜在的神经异常。
Brain plasticity is often associated with the process of slow-growing tumor formation, which remodels neural organization and optimizes brain network function. In this study, we aimed to investigate whether motor function plasticity would display deficits in patients with slow-growing brain tumors located in or near motor areas, but who were without motor neurological deficits. We used resting-state functional magnetic resonance imaging to probe motor networks in 15 patients with histopathologically confirmed brain gliomas and 15 age-matched healthy controls. All subjects performed a motor task to help identify individual motor activity in the bilateral primary motor cortex (PMC) and supplementary motor area (SMA). Frequency-based analysis at three different frequencies was then used to investigate possible alterations in the power spectral density (PSD) of low-frequency oscillations. For each group, the average PSD was determined for each brain region and a nonparametric test was performed to determine the difference in power between the two groups. Significantly reduced inter-hemispheric functional connectivity between the left and right PMC was observed in patients compared with controls (P<0.05). We also found significantly decreased PSD in patients compared to that in controls, in all three frequency bands (low: 0.01–0.02 Hz; middle: 0.02–0.06 Hz; and high: 0.06–0.1 Hz), at three key motor regions. These findings suggest that in asymptomatic patients with brain tumors located in eloquent regions, inter-hemispheric connection may be more vulnerable. A comparison of the two approaches indicated that power spectral analysis is more sensitive than functional connectivity analysis for identifying the neurological abnormalities underlying motor function plasticity induced by slow-growing tumors.
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影响因子：
3
作者：
Bajaj S;Drake D;Butler AJ;Dhamala M
通讯作者：
Dhamala M
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
2.5
作者：
Bianciardi, Marta;Fukunaga, Masaki;van Gelderen, Peter;Horovitz, Silvina G.;de Zwart, Jacco A.;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
11
作者：
Duffau, H;Capelle, L;Van Effenterre, R
通讯作者：
Van Effenterre, R
影响因子：
14.5
作者：
Bokde, ALW;Lopez-Bayo, P;Hampel, H
通讯作者：
Hampel, H