Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.
Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.
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DOI：
10.1016/j.coviro.2013.05.015
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发表时间：
2013-06
影响因子：
5.9
通讯作者：
Crotty, Shane
中科院分区：
文献类型：
--
作者：
Hu, Joyce;Havenar-Daughton, Colin;Crotty, Shane
产生长期体液免疫是成功疫苗的关键组成部分，需要生发中心（GC）的T细胞和B细胞之间的相互作用。在GCs中，CD4+辅助性T细胞的一个特殊子集，称为T滤泡辅助性T细胞（Tfh），为B细胞提供帮助；这有助于指导抗体反应的大小和质量。Tfh细胞有助于影响B细胞的存活、增殖、体细胞超突变、类开关重组和分化。Tfh细胞和B细胞之间的持续接触是为B细胞提供帮助所必需的。由Sh2d1a编码的信号淋巴细胞激活分子（SLAM）相关蛋白（SAP）调节T:B细胞相互作用的持续时间，是动物模型和人类长期体液免疫所必需的。SAP结合SLAM家族受体并介导影响细胞粘附、细胞因子分泌和TCR信号强度的信号传导。因此，SAP和SLAM家族受体表达的调节是疫苗接种后控制抗体反应质量和持续时间的主要轴。
Generating long-term humoral immunity is a crucial component of successful vaccines and requires interactions between T cells and B cells in germinal centers (GC). In GCs, a specialized subset of CD4+ helper T cells, called T follicular helper cells (Tfh), provide help to B cells; this help directs the magnitude and quality of the antibody response. Tfh cell help influences B cell survival, proliferation, somatic hypermutation, class switch recombination, and differentiation. Sustained contact between Tfh cells and B cells is necessary for the provision of help to B cells. SAP (Signaling lymphocytic activation molecule (SLAM)-associated protein, encoded by Sh2d1a) regulates the duration of T:B cell interactions and is required for long-term humoral immunity in animal models and in humans. SAP binds to SLAM family receptors and mediates signaling that affects cell adhesion, cytokine secretion, and TCR signaling strength. Therefore, the modulation of SAP and SLAM family receptor expression represents a major axis by which the quality and duration of an antibody response is controlled after vaccination.
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影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
64.8
作者：
Crotty, S;Kersh, EN;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
4.4
作者：
Graham, DB;Bell, MP;McKean, DJ
通讯作者：
McKean, DJ
影响因子：
30.3
作者：
Burton DR;Ahmed R;Barouch DH;Butera ST;Crotty S;Godzik A;Kaufmann DE;McElrath MJ;Nussenzweig MC;Pulendran B;Scanlan CN;Schief WR;Silvestri G;Streeck H;Walker BD;Walker LM;Ward AB;Wilson IA;Wyatt R
通讯作者：
Wyatt R