A Blueprint for HIV Vaccine Discovery.
A Blueprint for HIV Vaccine Discovery.
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DOI：
10.1016/j.chom.2012.09.008
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发表时间：
2012-10-18
影响因子：
30.3
通讯作者：
Wyatt R
中科院分区：
文献类型：
--
作者：
Burton DR;Ahmed R;Barouch DH;Butera ST;Crotty S;Godzik A;Kaufmann DE;McElrath MJ;Nussenzweig MC;Pulendran B;Scanlan CN;Schief WR;Silvestri G;Streeck H;Walker BD;Walker LM;Ward AB;Wilson IA;Wyatt R
尽管多年来基于经典策略开发艾滋病毒疫苗的多次尝试，到目前为止还没有令人信服的成功。在这一领域正在寻求一些方法，包括以最近的RV144临床试验所表明的可能的疗效为基础，该试验结合了两种艾滋病毒疫苗。在这里，我们主张一种方法，部分基于在分子水平上了解HIV包膜尖峰及其与广谱中和抗体(BNAbs)的相互作用，并利用这一理解将免疫原设计为可能的疫苗。在动物模型中，bNAbs可以抵抗病毒的攻击，最近已经分离出了许多这样的抗体。我们进一步提出，集中于如何最好地向产生bNAbs的B细胞提供T细胞帮助的研究对于最佳免疫策略至关重要。合理的免疫原设计和免疫策略的合成，加上迭代的改进，为迈向艾滋病毒疫苗提供了巨大的希望。
Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.
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影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
1
作者：
Chohan, Bhavna H.;Piantadosi, Anne;Overbaugh, Julie
通讯作者：
Overbaugh, Julie
影响因子：
5.4
作者：
Blish, Catherine A.;Dogan, Ozge C.;Overbaugh, Julie
通讯作者：
Overbaugh, Julie
影响因子：
3.7
作者：
Corti D;Langedijk JP;Hinz A;Seaman MS;Vanzetta F;Fernandez-Rodriguez BM;Silacci C;Pinna D;Jarrossay D;Balla-Jhagjhoorsingh S;Willems B;Zekveld MJ;Dreja H;O'Sullivan E;Pade C;Orkin C;Jeffs SA;Montefiori DC;Davis D;Weissenhorn W;McKnight A;Heeney JL;Sallusto F;Sattentau QJ;Weiss RA;Lanzavecchia A
通讯作者：
Lanzavecchia A
DOI：
10.1126/science.1175868
发表时间：
2009-11-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen L;Kwon YD;Zhou T;Wu X;O'Dell S;Cavacini L;Hessell AJ;Pancera M;Tang M;Xu L;Yang ZY;Zhang MY;Arthos J;Burton DR;Dimitrov DS;Nabel GJ;Posner MR;Sodroski J;Wyatt R;Mascola JR;Kwong PD
通讯作者：
Kwong PD