Inflammatory processes in cardiovascular disease: a route to targeted therapies.
Inflammatory processes in cardiovascular disease: a route to targeted therapies.
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DOI：
10.1038/nrcardio.2016.185
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Choudhury RP
中科院分区：
文献类型：
--
作者：
Ruparelia N;Chai JT;Fisher EA;Choudhury RP
炎症过程被牢固地确立为心血管疾病的发展和并发症的中心。炎症标志物水平升高已被证明是未来心血管事件的预测。在实验模型中，这些过程的特异性靶向已被证明可以减轻心肌和动脉损伤，减少疾病进展，并促进愈合。然而，这些观察结果的转化和临床实践中明确疗效的证明令人失望。一个主要的局限性可能是目前用于测量“炎症”的工具不够精确，不能提供有关疾病部位、活动或区分功能重要的激活途径的信息。因此，挑战在于制定更有意义的炎症指标，并指导特定的靶向治疗。在这篇综述中，我们通过对已知和新出现的炎症通路进行评估，来考虑炎症过程在动脉粥样硬化和急性心肌梗死（AMI）相关病理学中的作用。我们强调当代技术来表征和量化炎症，并考虑如何使用它们来指导特定的治疗。最后，我们讨论了在该领域出现的机会，包括目前的局限性和挑战，正在进行的研究的重点。
Inflammatory processes are firmly established as central to the development and complications of cardiovascular diseases. Elevated levels of inflammatory markers have been shown to be predictive of future cardiovascular events. The specific targeting of these processes in experimental models has been shown to attenuate myocardial and arterial injury, reduce disease progression, and promote healing. However, the translation of these observations and the demonstration of clear efficacy in clinical practice have been disappointing. A major limitation might be that tools currently used to measure ‘inflammation’ are insufficiently precise and do not provide information about disease site, activity, or discriminate between functionally important activation pathways. The challenge, therefore, is to make measures of inflammation that are more meaningful, and which can guide specific targeted therapies. In this Review, we consider the roles of inflammatory processes in the related pathologies of atherosclerosis and acute myocardial infarction (AMI), by providing an evaluation of the known and emerging inflammatory pathways. We highlight contemporary techniques to characterize and quantify inflammation, and consider how they might be used to guide specific treatments. Finally, we discuss emerging opportunities in the field, including current limitations and challenges that are the focus of ongoing study.
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影响因子：
7.5
作者：
Alam, Shirjel R.;Shah, Anoop S. V.;Semple, Scott I. K.
通讯作者：
Semple, Scott I. K.
DOI：
10.1126/science.1198704
发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
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Nolan GP
DOI：
10.1016/0735-1097(94)00443-t
发表时间：
1995-03-01
影响因子：
24
作者：
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通讯作者：
WEISMAN, H
影响因子：
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作者：
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通讯作者：
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