Pericardial and mediastinal fat-associated lymphoid clusters are rapidly activated in an alkane-induced model of systemic lupus erythematosus
Pericardial and mediastinal fat-associated lymphoid clusters are rapidly activated in an alkane-induced model of systemic lupus erythematosus
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在烷烃诱导的系统性红斑狼疮模型中，心包和纵隔脂肪相关淋巴簇被快速激活
DOI：
10.1093/discim/kyad017
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Bentkowska K
中科院分区：
文献类型：
--
作者：
Bentkowska K
系统性红斑狼疮（SLE）是一种以识别细胞成分的自身抗体为主的自身免疫性疾病。胸膜受累是最常见的slee相关肺部疾病。天然抗体由先天样B细胞在体内平衡紊乱后迅速分泌，在免疫激活的早期阶段起重要作用。浆液腔是大量先天样B细胞的家园，它们存在于浆液中，也存在于脂肪相关淋巴细胞簇（FALCs）中。FALCs是b细胞活化和体腔内局部抗体分泌的重要枢纽。SLE患者可产生抗磷脂抗体，并在极少数情况下发生肺泡出血。通过给C57BL/6小鼠注入烃类油嘌呤作为SLE模型，研究人员发现，早在给药后第3天，胸膜腔B细胞就迅速扩张。前列腺素输送后，心包B1 B细胞增殖，表达浆细胞表面标记物CD138，并分泌先天和类别转换抗体，这表明该腔位可能在狼疮性胸膜炎的发生中起着未被认识的作用。
Systemic lupus erythematosus (SLE) is an autoimmune disease predominated by auto-antibodies that recognise cellular components. Pleural involvement is the most common SLE-related lung disease. Natural antibodies are rapidly secreted by innate-like B cells following perturbation of homeostasis and are important in the early stages of immune activation. The serous cavities are home to large numbers of innate-like B cells present both within serous fluid and resident within fat-associated lymphoid clusters (FALCs). FALCs are important hubs for B-cell activation and local antibody secretion within the body cavities. Patients with SLE can develop anti-phospholipid antibodies and in rare situations develop alveolar haemorrhage. Utilising delivery of the hydrocarbon oil pristane in C57BL/6 mice as a model of SLE we identify a rapid expansion of pleural cavity B cells as early as day 3 after intra-peritoneal pristane delivery. Following pristane delivery, pericardial B1 B cells are proliferative, express the plasma-cell surface marker CD138, and secrete both innate and class-switched antibodies highlighting that this cavity niche may play an unrecognised role in the initiation of lupus pleuritis.
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DOI：
10.1002/art.40077
发表时间：
2017-06
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Zhuang H;Han S;Lee PY;Khaybullin R;Shumyak S;Lu L;Chatha A;Afaneh A;Zhang Y;Xie C;Nacionales D;Moldawer L;Qi X;Yang LJ;Reeves WH
通讯作者：
Reeves WH
DOI：
10.1016/j.clim.2014.06.007
发表时间：
2014-09
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Pawar RD;Goilav B;Xia Y;Zhuang H;Herlitz L;Reeves WH;Putterman C
通讯作者：
Putterman C
影响因子：
9.6
作者：
GOOD, JT;KING, TE;SAHN, SA
通讯作者：
SAHN, SA
影响因子：
16.8
作者：
Reeves WH;Lee PY;Weinstein JS;Satoh M;Lu L
通讯作者：
Lu L
人类 CD5 B 细胞在腹膜腔中的优先定位
影响因子：
3.7
作者：
S. Nisitani;M. Murakami;T. Akamizu;T. Okino;K. Ohmori;T. Mori;M. Imamura;T. Honjo
通讯作者：
T. Honjo