The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer.
The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer.
复制标题
DOI：
10.3390/ijms23169313
复制
发表时间：
2022-08-18
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
稳健、严格调控的 DNA 修复对于维持基因组稳定性和预防癌症至关重要。真核 DNA 被包装到染色质中，染色质对 DNA 修复和基因组稳定性具有深远但尚未完全了解的调节影响。染色质重塑因子 HELLS（解旋酶，淋巴特异性）已成为 DNA 修复、基因组稳定性和多种癌症相关途径的重要表观遗传调节因子。 HELLS 属于保守的 SNF2 ATP 依赖性染色质重塑复合物的一个亚家族，该复合物在 DNA 复制、转录和修复过程中利用 ATP 水解产生的能量来改变核小体结构和染色质包装。小鼠同源物 LSH（淋巴特异性解旋酶）在异染色质和全基因组 DNA 甲基化的维持中发挥着重要作用，并且在胚胎发育、配子发生和免疫系统成熟中至关重要。人类 HELLS 在淋巴组织、皮肤、生殖细胞和胚胎干细胞的高度增殖细胞中大量表达。 HELLS 中的突变会导致人类免疫缺陷综合症 ICF（免疫缺陷、着丝粒不稳定、面部异常）。 HELLS 与多种癌症有关，包括视网膜母细胞瘤、结直肠癌、肝细胞癌和胶质母细胞瘤。在这里，我们回顾并总结了积累的证据，强调了 HELLS 在 DNA 修复、基因组维护以及与癌症发生、进展和治疗相关的关键途径中的重要作用。
Robust, tightly regulated DNA repair is critical to maintaining genome stability and preventing cancer. Eukaryotic DNA is packaged into chromatin, which has a profound, yet incompletely understood, regulatory influence on DNA repair and genome stability. The chromatin remodeler HELLS (helicase, lymphoid specific) has emerged as an important epigenetic regulator of DNA repair, genome stability, and multiple cancer-associated pathways. HELLS belongs to a subfamily of the conserved SNF2 ATP-dependent chromatin-remodeling complexes, which use energy from ATP hydrolysis to alter nucleosome structure and packaging of chromatin during the processes of DNA replication, transcription, and repair. The mouse homologue, LSH (lymphoid-specific helicase), plays an important role in the maintenance of heterochromatin and genome-wide DNA methylation, and is crucial in embryonic development, gametogenesis, and maturation of the immune system. Human HELLS is abundantly expressed in highly proliferating cells of the lymphoid tissue, skin, germ cells, and embryonic stem cells. Mutations in HELLS cause the human immunodeficiency syndrome ICF (Immunodeficiency, Centromeric instability, Facial anomalies). HELLS has been implicated in many types of cancer, including retinoblastoma, colorectal cancer, hepatocellular carcinoma, and glioblastoma. Here, we review and summarize accumulating evidence highlighting important roles for HELLS in DNA repair, genome maintenance, and key pathways relevant to cancer development, progression, and treatment.
登录
查看更多内容
染色质重塑因子 LSH 通过抑制富马酸水合酶的活性来驱动癌症进展
影响因子：
11.2
作者：
He X;Yan B;Liu S;Jia J;Lai W;Xin X;Tang CE;Luo D;Tan T;Jiang Y;Shi Y;Liu Y;Xiao D;Chen L;Liu S;Mao C;Yin G;Cheng Y;Fan J;Cao Y;Muegge K;Tao Y
通讯作者：
Tao Y
影响因子：
4
作者：
Hou X;Yang L;Wang K;Zhou Y;Li Q;Kong F;Liu X;He J
通讯作者：
He J
影响因子：
4
作者：
Burrage, Joe;Termanis, Ausma;Stancheva, Irina
通讯作者：
Stancheva, Irina
影响因子：
14.9
作者：
Litwin I;Bakowski T;Maciaszczyk-Dziubinska E;Wysocki R
通讯作者：
Wysocki R
DOI：
10.1016/s0304-4165(01)00129-5
发表时间：
2001-05-03
影响因子：
3
作者：
Geiman, TM;Tessarollo, L;Muegge, K
通讯作者：
Muegge, K