Guideline concordance and antibiotic-associated adverse events between Veterans administration and non-Veterans administration dental settings: a retrospective cohort study.
Guideline concordance and antibiotic-associated adverse events between Veterans administration and non-Veterans administration dental settings: a retrospective cohort study.
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DOI：
10.3389/fphar.2024.1249531
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发表时间：
2024
影响因子：
5.6
通讯作者：
Suda KJ
中科院分区：
文献类型：
--
作者：
Ramanathan S;Evans CT;Hershow RC;Calip GS;Rowan S;Hubbard C;Suda KJ
背景：牙科手术前作为感染预防的抗生素有可能导致严重药物不良事件（ADE）。然而，指南的一致性和不同的牙科环境与抗生素预防的ADE的相关程度尚不清楚。 目的：目的是评估指南一致性和卒中相关ADE，以及VA和非VA设置是否存在差异。 方法：回顾性队列研究，对2015年至2017年期间患有心脏病或人工关节的成人进行抗生素预防性治疗。拟合多变量逻辑回归模型以评估ADE、指南一致性和牙科环境的影响。一致性和牙科环境的相互作用项评估ADE和一致性之间的关系是否因环境而异。 结果：从2015年到2017年，确定了61，124例抗生素预防患者，其中62例（0.1%）发生ADE。在与指南一致的患者中，18例（0.09%）发生了ADE，而在使用不一致抗生素的患者中，44例（0.1%）发生了ADE（未校正OR：0.84，95% CI：0.49-1.45）。校正后的分析显示，指南一致性与ADE无关（OR：0.78，95% CI：0.25-2.46），并且这种关系在牙科环境中没有差异（Wald χ^2相互作用p值= 0.601）。 结论：抗生素相关ADE在不同环境或指南一致性方面无差异。
Background: Antibiotics prescribed as infection prophylaxis prior to dental procedures have the potential for serious adverse drug events (ADEs). However, the extent to which guideline concordance and different dental settings are associated with ADEs from antibiotic prophylaxis is unknown. Aim: The purpose was to assess guideline concordance and antibiotic-associated ADEs and whether it differs by VA and non-VA settings. Methods: Retrospective cohort study of antibiotic prophylaxis prescribed to adults with cardiac conditions or prosthetic joints from 2015 to 2017. Multivariable logistic regression models were fit to assess the impact of ADEs, guideline concordance and dental setting. An interaction term of concordance and dental setting evaluated whether the relationship between ADEs and concordance differed by setting. Results: From 2015 to 2017, 61,124 patients with antibiotic prophylaxis were identified with 62 (0.1%) having an ADE. Of those with guideline concordance, 18 (0.09%) had an ADE while 44 (0.1%) of those with a discordant antibiotic had an ADE (unadjusted OR: 0.84, 95% CI: 0.49–1.45). Adjusted analyses showed that guideline concordance was not associated with ADEs (OR: 0.78, 95% CI: 0.25–2.46), and this relationship did not differ by dental setting (Wald χ^2 p-value for interaction = 0.601). Conclusion: Antibiotic-associated ADEs did not differ by setting or guideline concordance.
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影响因子：
11.8
作者：
Carignan, Alex;Allard, Catherine;Valiquette, Louis
通讯作者：
Valiquette, Louis
影响因子：
4.2
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影响因子：
4.5
作者：
Gross, Alan E.;Suda, Katie J.;McGregor, Jessina C.
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McGregor, Jessina C.
DOI：
10.2106/00004623-201304170-00011
发表时间：
2013-04-17
影响因子：
5.3
作者：
Rethman, Michael P.;Watters, William, III;Hanson, Nicholas Buck
通讯作者：
Hanson, Nicholas Buck
DOI：
10.1016/j.japh.2016.08.015
发表时间：
2016-11-01
影响因子：
2.1
作者：
Suda, Katie J.;Roberts, Rebecca M.;Taylor, Thomas H.
通讯作者：
Taylor, Thomas H.