Entropy analysis of tri-axial leg acceleration signal waveforms for measurement of decrease of physiological variability in human gait.
Entropy analysis of tri-axial leg acceleration signal waveforms for measurement of decrease of physiological variability in human gait.
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DOI：
10.1002/jor.22022
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发表时间：
2012-06
影响因子：
2.8
通讯作者：
Brown, Thomas D.
中科院分区：
文献类型：
--
作者：
Tochigi, Yuki;Segal, Neil A.;Vaseenon, Tanawat;Brown, Thomas D.
关键词：
与疾病相关的、衰老的生物时间序列输出(如心率)中的生理变异性的降低作为一种潜在的新型生物标志物已经引起了越来越多的关注。在这个范例中，对周期性运动的可变性的测量可以对肌肉骨骼疾病患者的功能限制进行定量评估。采用一种新的技术来测量水平行走过程中腿部运动模式的变异性，研究对象为52名患有症状性膝骨性关节炎(OA)的成年人和57名年龄范围广泛(20-79岁)的无症状对照组受试者。这个假设是，腿部运动模式的周期变异性，以三轴加速度信号熵为指标，在年龄较大或有膝部症状的人中会更低。使用安装在两侧脚踝上方的便携式惯性监测器来评估腿部运动。使用名为样本熵(SampEn)的非线性变异性测量工具对三轴加速度数据进行分析。无症状受试者的SampEn数据与年龄呈显著负相关(r=-0.287，p=0.0306)。OA受试者的SampEn值显著低于以相同速度行走的年龄匹配的无症状受试者(p=0.0002)。这一方法有望成为有效、廉价和方便地客观评估人类步态功能局限性的基础。
Disease-related and senescent decrease of physiological variability in biological time-series outputs (e.g., heart rate) has drawn increasing attention as a potential new type of biomarker. In this paradigm, measurement of variability in periodic motion may enable quantitative evaluation of functional limitation in people with musculoskeletal disorders. A novel technique to measure variability of leg motion patterns during level walking was used to study 52 adults with symptomatic knee osteoarthritis (OA), and 57 asymptomatic control subjects over a wide range of age (20 to 79 years). The hypothesis was that cycle-to-cycle variability in leg motion patterns, indexed by tri-axial acceleration signal entropy, would be lower in those with greater age or with knee symptoms. Leg motions were assessed using portable inertial monitors attached bilaterally just above each ankle. The tri-axial acceleration data were analyzed using a non-linear variability measurement tool designated as Sample Entropy (SampEn). SampEn data for asymptomatic subjects exhibited a significant negative correlation (r = -0.287, p = 0.0306) with greater age. OA subjects had significantly lower SampEn values (p = 0.0002) than did age-matched asymptomatic subjects who walked at equivalent velocity. This approach holds promise as a basis for valid, inexpensive, and convenient objective evaluation of limitations in human gait function.
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影响因子：
5.3
作者：
Xu, Lisheng;Meng, Max Q. -H.;Wang, Kuanquan
通讯作者：
Wang, Kuanquan
影响因子：
2.2
作者：
Georgoulis, Anastasios D;Moraiti, Constantina;Stergiou, Nicholas
通讯作者：
Stergiou, Nicholas
影响因子：
--
作者：
SHANNON, CE
通讯作者：
SHANNON, CE
DOI：
10.1046/j.1532-5415.2001.4911247.x
发表时间：
2001-11-01
影响因子：
6.3
作者：
Simonsick, EM;Montgomery, PS;Harris, T
通讯作者：
Harris, T
影响因子：
0.7
作者：
Kimura, Tasuku;Kobayashi, Hiromitsu;Hanaoka, Michiko
通讯作者：
Hanaoka, Michiko