Radiotherapy for childhood cancer and risk for congenital malformations in offspring: a population-based cohort study.
Radiotherapy for childhood cancer and risk for congenital malformations in offspring: a population-based cohort study.
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DOI：
10.1111/j.1399-0004.2008.01109.x
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发表时间：
2009-01
影响因子：
3.5
通讯作者：
Olsen JH
中科院分区：
文献类型：
--
作者：
Winther JF;Boice JD Jr;Frederiksen K;Bautz A;Mulvihill JJ;Stovall M;Olsen JH
儿童癌症幸存者的后代可能由于其父母接受的诱变癌症治疗而有遗传疾病的风险。先天性畸形在一项基于人群的队列研究中进行了评估，该研究包括3963名儿童癌症幸存者的1715名后代和5657名幸存者兄弟姐妹的6009名后代。丹麦中央人口登记处、癌症登记处和医院登记处用于确定研究受试者和先天性畸形。根据标准放射治疗方案，对性腺和子宫的放射剂量进行了表征。幸存者后代出生时先天畸形的患病率（44例，2.6%）略高于同胞子女，但无统计学差异（140例，2.3%）[患病率比例比（PPR），1.1; 95%置信区间，0.8- 1.5]或一般人群（预测值与预期值之比，1.2; 0.9- 1.6）。包括后来诊断出的畸形并没有明显改变比例。畸形的风险是略高于在未照射的父母（PPR 1.2比1.0），但与性腺剂量照射的父母的后代。这项研究提供的证据表明，儿童癌症治疗不会增加其后代畸形的风险。然而，有必要继续监测其后代的遗传风险。
Offspring of childhood cancer survivors may be at risk of genetic disease due to the mutagenic cancer treatments received by their parents. Congenital malformations were evaluated in a population-based cohort study of 1715 offspring of 3963 childhood cancer survivors and 6009 offspring of 5657 survivors’ siblings. The Danish Central Population Register, Cancer Registry and Hospital Register were used to identify study subjects and congenital malformations. Gonadal and uterine radiation doses were characterized based on standard radiation-treatment regimens. The prevalence of congenital malformations at birth in offspring of survivors (44 cases, 2.6%) was slightly higher but not statistically different from that of offspring of siblings (140 cases, 2.3%) [prevalence proportion ratio (PPR), 1.1; 95% confidence interval, 0.8– 1.5] or of the general population (observed-to-expected ratio, 1.2; 0.9– 1.6). Including malformations diagnosed later in life did not change the ratios appreciably. The risk for malformations was slightly higher in the offspring of irradiated parents than in that of non-irradiated parents (PPR 1.2 vs 1.0) but was unrelated to gonadal dose. This study provides evidence that cancer therapy of children does not increase the risk for malformations in their offspring. Continued monitoring of genetic risks among their offspring, however, is warranted.
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影响因子：
120.7
作者：
LI, FP;GIMBRERE, K;MEADOWS, AT
通讯作者：
MEADOWS, AT
影响因子：
45.3
作者：
Winther, Jeanette F.;Boice, John D., Jr.;Olsen, Jorgen H.
通讯作者：
Olsen, Jorgen H.
DOI：
10.1016/j.ijrobp.2003.08.031
发表时间：
2004-04-01
影响因子：
7
作者：
Kalapurakal, JA;Peterson, S;Breslow, NE
通讯作者：
Breslow, NE
影响因子：
3.4
作者：
OTAKE, M;SCHULL, WJ;NEEL, JV
通讯作者：
NEEL, JV
影响因子：
6.4
作者：
BIRCH, JM;MARSDEN, HB
通讯作者：
MARSDEN, HB