Secondary metabolism in fungi: does chromosomal location matter?
Secondary metabolism in fungi: does chromosomal location matter?
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DOI：
10.1016/j.mib.2010.04.008
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发表时间：
2010-08
影响因子：
5.4
通讯作者：
Keller, Nancy P.
中科院分区：
文献类型：
--
作者：
Palmer, Jonathan M.;Keller, Nancy P.
丝状真菌产生大量称为次级代谢物的小分子，其中包括毒素和抗生素。共调控基因簇是真菌次生代谢的标志，越来越多的证据表明，调控至少部分是表观遗传的。染色质水平的控制涉及在真菌中观察到的几种沉默现象，包括交配型转换，端粒位置效应，核糖体DNA的沉默，参与营养物质获取的基因的调节，以及如这里所呈现的，次级代谢物簇表达。这些现象是由染色体位置的潜在主题联系在一起的，通常在着丝粒和端粒附近，其中兼性异染色质在转录中起作用。次级代谢物基因簇通常位于亚端粒，最近已经表明参与染色质重塑的蛋白质，如LaeA，ClrD，CclA和HepA介导簇调节。
Filamentous fungi produce a vast array of small molecules called secondary metabolites, which include toxins as well as antibiotics. Co-regulated gene clusters are the hallmark of fungal secondary metabolism, and there is a growing body of evidence that suggests regulation is at least, in part, epigenetic. Chromatin-level control is involved in several silencing phenomena observed in fungi including mating type switching, telomere position effect, silencing of ribosomal DNA, regulation of genes involved in nutrient acquisition, and as presented here, secondary metabolite cluster expression. These phenomena are tied together by the underlying theme of chromosomal location, often near centromeres and telomeres, where facultative heterochromatin plays a role in transcription. Secondary metabolite gene clusters are often located sub-telomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA and HepA mediate cluster regulation.
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影响因子：
4.4
作者：
Chiang, Yi-Ming;Szewczyk, Edyta;Oakley, Berl R.
通讯作者：
Oakley, Berl R.
影响因子：
16
作者：
Freitag, M;Hickey, PC;Selker, EU
通讯作者：
Selker, EU
影响因子：
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作者：
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通讯作者：
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通讯作者：
Keller, Nancy P.
影响因子：
4
作者：
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通讯作者：
Grewal, Shiv I. S.