Nutrient-induced intestinal adaption and its effect in obesity.
Nutrient-induced intestinal adaption and its effect in obesity.
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DOI：
10.1016/j.physbeh.2014.03.026
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发表时间：
2014-09
影响因子：
2.9
通讯作者：
Dailey MJ
中科院分区：
文献类型：
--
作者：
Dailey MJ
肥胖和瘦个体对营养的反应不同，消化，吸收和激素释放发生变化。这可能是由过度进食或与肥胖相关的饮食类型驱动的肠上皮形态和功能差异的结果。众所周知，肠的维持和生长是由管腔营养物的量驱动的，高营养物含量导致细胞数量、绒毛长度和隐窝深度的增加。此外，营养素的类型似乎有助于改变上皮细胞的形态和功能。这种肠道适应可能是导致瘦个体与肥胖个体营养加工差异的原因。本文综述了营养素如何能够诱导肠上皮细胞增殖、分化和功能的变化，以及肠适应和肥胖之间的联系。
Obese and lean individuals respond differently to nutrients with changes in digestion, absorption and hormone release. This may be a result of differences in intestinal epithelial morphology and function driven by the hyperphagia or the type of diet associated with obesity. It is well known that the maintenance and growth of the intestine is driven by the amount of luminal nutrients, with high nutrient content resulting in increases in cell number, villi length and crypt depth. In addition, the type of nutrient appears to contribute to alterations in the morphology and function of the epithelial cells. This intestinal adaptation may be what is driving the differences in nutrient processing in lean versus obese individuals. This review describes how nutrients may be able to induce changes in intestinal epithelial cell proliferation, differentiation and function and the link between intestinal adaptation and obesity.
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影响因子：
1.9
作者：
Malinauskas, Tomas
通讯作者：
Malinauskas, Tomas
影响因子：
11.4
作者：
Jenny, M;Uhl, C;Gradwohl, G
通讯作者：
Gradwohl, G
影响因子：
16
作者：
Chocarro-Calvo, Ana;Manuel Garcia-Martinez, Jose;Garcia-Jimenez, Custodia
通讯作者：
Garcia-Jimenez, Custodia
影响因子：
--
作者：
CAREY, HV;COOKE, HJ
通讯作者：
COOKE, HJ
DOI：
10.1152/ajpgi.00024.2006
发表时间：
2007-02-01
影响因子：
4.5
作者：
Brun, Paola;Castagliuolo, Ignazio;Martines, Diego
通讯作者：
Martines, Diego