Tumor-associated, estrogen receptor-related antigen EBAG9: linking intracellular vesicle trafficking, immune homeostasis, and malignancy.
Tumor-associated, estrogen receptor-related antigen EBAG9: linking intracellular vesicle trafficking, immune homeostasis, and malignancy.
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DOI：
10.1124/mi.9.6.4
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发表时间：
2009-12
影响因子：
--
通讯作者：
Chrousos GP
中科院分区：
文献类型：
--
作者：
Kino T;Chrousos GP
Cytotoxic T-lymphocyte- and natural killer cell-mediated cytotoxic immune surveillance is crucial for preventing development and growth of malignancies. A recent intriguing study by Rüder et al. demonstrated that the estrogen receptor-related and tumor-associated EBAG9 (Estrogen receptor-Binding fragment-Associated Gene 9) protein acted as a novel inhibitor of cytotoxic immune responses, potentially influencing growth and spread of malignancies. EBAG9 did this by suppressing production of secretory lysosomes through negative regulation of adaptor proteins involved in intracellular vesicle transfer. Secretory lysosomes contain cell lysis effector molecules released into the immune synapse formed between cytotoxic immune cells and their target tumor cells. Thus, in addition to their direct ER-mediated suppressive effect on estrogen-dependent tumor growth, anti-estrogens may employ EBAG9 as a molecular switch to activate immune cytotoxicity against these cancer cells.
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影响因子：
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