Kawasaki Disease Shock Syndrome vs Classical Kawasaki Disease: A Meta-analysis and Comparison With SARS-CoV-2 Multisystem Inflammatory Syndrome.
Kawasaki Disease Shock Syndrome vs Classical Kawasaki Disease: A Meta-analysis and Comparison With SARS-CoV-2 Multisystem Inflammatory Syndrome.
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川崎疾病休克综合征与古典川崎病：与SARS-COV-2多系统炎症综合征的荟萃分析和比较。
DOI：
10.1016/j.cjca.2021.05.014
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Dahdah N
中科院分区：
文献类型：
--
作者：
Lamrani L;Manlhiot C;Elias MD;Choueiter NF;Dionne A;Harahsheh AS;Portman MA;McCrindle BW;Dahdah N
世界范围内越来越多关于类似川崎病 (KD) 的儿科患者出现严重炎症过程和休克的报道，更具体地说，川崎病休克综合征 (KDSS)，促使我们在这两种疾病之间进行系统比较的序言中探讨 KDSS。我们完成了对 KDSS 的系统评价，并对报告的 KDSS 病例和 KD 对照进行了荟萃分析比较。荟萃分析中总共纳入了 10 个病例对照系列。与标准 KD 患者相比，KDSS 患者年龄较大（38.4 ± 30.6 个月 vs 21.9 ± 19.5 个月；P < 0.001），且性别分布相同且临床诊断标准完整。 KDSS 呈现较高的 C 反应蛋白（59.4 ± 29.2 mg/dL vs 20.8 ± 14.8 mg/dL；P < 0.001）、较低的白蛋白（2.7 ± 0.5 g/dL vs 3.3 ± 0.5 g/dL；P < 0.01）和较低的血小板（255 ± 149 109/L vs 394 ± 132 109/L；P < 0.001），但白细胞仅处于临界水平（P = 0.06）。丙氨酸转氨酶、天冬氨酸转氨酶和红细胞沉降率的差异不显着。 KDSS 中静脉免疫球蛋白抵抗的几率（44.4% vs 9.6%；（P < 0.001））和住院时间（10.9 ± 5.8 vs 5.0 ± 3.0 天；P < 0.001）较高，冠状动脉异常的几率也较高（33.9% vs 8.6%；P < 0.001）。 KDSS 与 KD 为未来 KDSS 工作奠定了基础，并为未来寻找 KDSS 表现要素与最终并发症之间的因果关系提供了机会。儿童 SARS-CoV-2 多系统炎症综合征与 KDSS 之间的相似性为了解 KDSS 的病因学和病理生理学开辟了新的视野。
The emergence of increasing reports worldwide of a severe inflammatory process and shock in pediatric patients resembling Kawasaki disease (KD)—and, more specifically, Kawasaki disease shock syndrome (KDSS)—prompted us to explore KDSS in a preamble of a systematic comparison between the 2 conditions. We completed a systematic review of KDSS and performed a meta-analysis comparison between reported KDSS cases and KD controls. A total of 10 case-control series were included in the meta-analysis. Patients with KDSS were older (38.4 ± 30.6 vs 21.9 ± 19.5 months; P < 0.001) compared with standard KD with equal sex distribution and completeness of clinical diagnostic criteria. KDSS present higher C-reactive protein (59.4 ± 29.2 mg/dL vs 20.8 ± 14.8 mg/dL; P < 0.001), lower albumin (2.7 ± 0.5 g/dL vs 3.3 ± 0.5 g/dL; P < 0.01), and lower platelets (255 ± 149 109/L vs 394 ± 132 109/L; P < 0.001) but only borderline higher white blood cells (P = 0.06). Differences in alanine transaminase, aspartate aminotransferase, and erythrocyte sedimentation rate were nonsignificant. The odds of intravenous immunoglobulin resistance (44.4% vs 9.6%; (P < 0.001) and the hospital length of stay (10.9 ± 5.8 vs 5.0 ± 3.0 days; P < 0.001) were higher in KDSS, as were the odds of coronary-artery abnormalities (33.9% vs 8.6%; P < 0.001). This first meta-analysis on KDSS vs KD represents a basis for future works on KDSS and opens the opportunity for future multicentre studies in the search of causal relationships between presenting elements and the eventual complications of KDSS. The similarities between SARS-CoV-2 multisystem inflammatory syndrome in children and KDSS open new horizons to the understanding of the etiology and pathophysiology related to KDSS.
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影响因子：
36.4
作者：
Goetzinger, Florian;Santiago-Garcia, Begona;Tebruegge, Marc
通讯作者：
Tebruegge, Marc
影响因子：
1.4
作者：
Berenise Gamez-Gonzalez, Luisa;Moribe-Quintero, Isabel;Yamazaki-Nakashimada, Marco
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Yamazaki-Nakashimada, Marco
影响因子：
8
作者：
Dominguez, Samuel R.;Friedman, Kevin;Glode, Mary P.
通讯作者：
Glode, Mary P.
DOI：
10.1016/j.jmii.2013.06.005
发表时间：
2015-02-01
影响因子：
7.4
作者：
Chen, Pei-Shin;Chi, Hsin;Chiu, Nan-Chang
通讯作者：
Chiu, Nan-Chang
影响因子：
33.9
作者：
Godfred-Cato, Shana;Bryant, Bobbi;Belay, Ermias
通讯作者：
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