New Functions for PI3K in the Control of Cell Division
New Functions for PI3K in the Control of Cell Division
复制标题
PI3K 控制细胞分裂的新功能
作者：
Amit Kumar;A. Carrera
虽然细胞脂质最初被设想为细胞的结构组分，但它们对细胞反应的启动和调节的重要贡献现在已经明确确立。在调节细胞反应的不同脂质中，由I类磷脂酰肌醇3-激酶（PI 3 K）、磷脂酰肌醇（3，4）P2（PIP 2）和磷脂酰肌醇（3，4，5）P3（PIP 3）产生的那些脂质近年来引起了广泛关注。PIP 2和PIP 3参与细胞分裂和存活控制，PI 3 K通路的突变与自身免疫和癌症有关。在这里，我们讨论了两个新的观察：PI 3 K的功能在细胞周期的后期G1期和贡献的p85 PI 3 K调节亚基在胞质分裂的控制。
Although cell lipids were initially envisioned as structural components of the cell, their essential contribution to initiation and regulation of cell responses is now clearly established. Among the different lipids that regulate cell responses, those produced by class I phosphoinositide 3-kinase (PI3K), phosphatidylinositol (3,4)P2 (PIP2), and phosphatidylinositol (3,4,5)P3 (PIP3), have concentrated much attention in recent years. PIP2 and PIP3 are involved in cell division and survival control, and mutations in the PI3K pathway are linked to autoimmunity and cancer. Here we discuss two novel observations: a PI3K function in the late-G1 phase of the cell cycle and the contribution of the p85 PI3K regulatory subunit in the control of cytokinesis.
影响因子：
4
作者：
D. Stacey;A. Kazlauskas
通讯作者：
D. Stacey;A. Kazlauskas
c-myc 表达对非转化细胞增殖、静止和 G0 到 G1 转变的影响。
DOI：
--
发表时间：
1993
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
影响因子：
--
作者：
Shichiri,M;Hanson,KD;Sedivy,JM
通讯作者：
Sedivy,JM
影响因子：
3.3
作者：
Caviston, JP;Longtine, M;Bi, E
通讯作者：
Bi, E