Mechanical Strength Improvement of Apatite Cement Using Hydroxyapatite/Collagen Nanocomposite
Mechanical Strength Improvement of Apatite Cement Using Hydroxyapatite/Collagen Nanocomposite
复制标题
使用羟基磷灰石/胶原纳米复合材料提高磷灰石水泥的机械强度
DOI：
10.4028/www.scientific.net/kem.720.167
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
M. Kikuchi
中科院分区：
文献类型：
--
作者：
Arief Cahyanto;K. Tsuru;K. Ishikawa;M. Kikuchi
磷酸四钙（TTCP; Ca 4（PO 4）2 O）和无水磷酸二钙（DCPA; CaHPO 4）的组合，其已知为已用于医疗和牙科应用的磷灰石粘固剂的一种系统。尽管磷灰石水泥具有一些优点，如自固化能力和生物相容性，但其机械强度仍然较低。本研究的目的是使用羟基磷灰石/胶原纳米复合材料（HAp/Col）提高TTCP-DCPA磷灰石水泥的机械强度。使用等摩尔的TTCP和DCPA，添加10%和20%的HAp/Col制备磷灰石水泥粉末。将各组与lmol/L Na1.8H1.2PO4水溶液以0.5的粉液比混合，并在37°C和100%相对湿度下硬化24小时。根据牙科磷酸锌粘固剂的ISO 1566，使用Vicat针评价粘固剂的凝固时间。用扫描电镜（SEM）观察水泥固化体的形貌，用X射线衍射仪（XRD）鉴定水泥的晶相。通过径向抗拉强度（DNT）评价骨水泥凝固的机械强度。含HAp/Col的骨水泥的凝固时间最短，对照组最长。混合后24小时的水泥的XRD图案显示，所有水泥从TTCP和DCPA的混合物转变为磷灰石。含20%HAp/Col的水泥的DTS最高，对照最低，且含20%HAp/Col的水泥与其他两种水泥之间存在显著差异。水泥表面和断裂面的扫描电子显微照片表明，与对照相比，具有HAp/Col的水泥显示出更致密的结构，并且HAp/Col纤维和/或片覆盖断裂面。HAp/Col既可作为增强纤维，又可作为TTCP与DCPA反应生成的磷灰石颗粒的粘结剂。加入20%HAp/Col后，磷灰石骨水泥的固化时间和机械强度均得到显著提高。
The combination of tetracalcium phosphate (TTCP; Ca4(PO4)2O) and dicalcium phosphate anhydrous (DCPA; CaHPO4) which are known as one system of apatite cements already used in the medical and dental application. In spite of several advantages of apatite cements, such as self-setting ability and biocompatibility, their mechanical strengths are still low. The aim of this study is to improve the mechanical strength of the TTCP-DCPA apatite cement using the hydroxyapatite/collagen nanocomposite (HAp/Col). The apatite cement powder was prepared using an equimolar TTCP and DCPA with addition of 10% and 20% of the HAp/Col. That without the HAp/Col was used as a control group. Each group was mixed with 1 mol/L Na1.8H1.2PO4 aqueous solution at powder/liquid ratio of 0.5 and hardened at 37°C and 100 % of relative humidity for 24 hours. A setting time of the cement was evaluated using Vicat needle according to ISO 1566 for dental zinc phosphate cements. Morphology of the cements set were observed by the scanning electron microscopy (SEM), and crystalline phases were identified by the powder X-Ray diffractometry (XRD). The mechanical strength of the cement set was evaluated by the diametral tensile strength (DTS). The setting times of cements were the shortest for the cement with HAp/Col and the longest for the control. XRD patterns of the cement at 24 hours after mixing revealed that all cements changed into apatite from the mixture of TTCP and DCPA. The DTSs of cements were the highest for the cement with 20% HAp/Col and the lowest for the control with significant differences between the cement with 20 % HAp/Col and respective other two cements. The scanning electron micrographs of the surface and fracture surface of the cements suggested that the cement with HAp/Col showed denser structure in comparison to the control and the HAp/Col fibers and/or sheets covered the fracture surface. The HAp/Col would act as reinforcement fibers as well as an adhesive of apatite granules formed by the reaction between TTCP and DCPA. The setting time and mechanical strength of apatite cement was statistically significant improved by adding 20% HAp/Col.
影响因子：
14
作者：
Kikuchi, M;Itoh, S;Tanaka, J
通讯作者：
Tanaka, J