Schistosoma mansoni infection in a rural area of the Jequitinhonha Valley, Minas Gerais, Brazil: analysis of exposure risk.

Schistosoma mansoni infection in a rural area of the Jequitinhonha Valley, Minas Gerais, Brazil: analysis of exposure risk.
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巴西米纳斯·格拉斯(Minas Gerais)的Jequitinhonha山谷农村地区的曼森感染血吸虫感染:暴露风险分析。

DOI:
10.1016/j.actatropica.2009.09.001
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发表时间:
2010-01
期刊:
影响因子:
2.7
通讯作者:
Gazzinelli A
Gazzinelli A
中科院分区:
医学2区
文献类型:
--
作者:
Pereira WR;Kloos H;Crawford SB;Velásquez-Melendez JG;Matoso LF;Fujiwara RT;Cançado GG;Loverde PT;Correa-Oliveira R;Gazzinelli A

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本研究探讨了年龄特异性总IgE水平、嗜酸性粒细胞和水接触行为对米纳斯吉拉斯州北部Virgem das gra<s:1> as贫困农村人口中曼氏血吸虫感染流行率和强度(几何平均卵数)的相对贡献。在双变量分析中,年龄与感染的患病率和感染的强度密切相关,而嗜酸性粒细胞水平仅与患病率相关(p<0.0001);IgE水平和5个人口统计学和社会经济变量与患病率有中度相关性(p<0.05),每个房间的人数和TBM(总身体分钟)与鸡蛋数也有中度相关性。在多因素分析中,在控制人口统计学和社会经济因素后,只有总IgE水平与感染患病率(p=0.248, 95% CI= 1.01-1.11)和感染强度(p=0.0217, 95% CI= 0.01-0.14)和嗜酸性粒细胞水平与患病率(p=0.0005, 95% CI= 1.07-1.24)显著相关。尽管横断面研究无法证实任何因果关系,但我们证明了IgE水平升高会降低曼氏链球菌感染的患病率和强度。
This study examines the relative contribution of age-specific total IgE levels, eosinophils and water contact behavior to the prevalence and intensity (geometric mean egg counts) of Schistosoma mansoni infection in the poor rural population of Virgem das Graças in northern Minas Gerais State. In bivariate analysis, age was strongly correlated with both prevalence and intensity of infection, while eosinophil levels with prevalence only (p<0.0001); IgE levels and 5 demographic and socioeconomic variables were moderately correlated with prevalence (p<0.05), as were number of persons per room and TBM (total body minutes) with egg counts. In multivariate analysis, after controlling for demographic and socioeconomic factors, only total IgE levels were significantly correlated with both prevalence (p=0.248, 95% CI= 1.01–1.11) and intensity (p=0.0217, 95% CI=0.01–0.14) of infection and eosinophil levels with prevalence (p=0.0005, 95% CI=1.07–1.24). Although any causal relationship cannot be confirmed by a cross-sectional study, we demonstrated an associated decrease in prevalence and intensity of S. mansoni infection with increased IgE levels.
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