Complex Virus-Host Interactions Involved in the Regulation of Classical Swine Fever Virus Replication: A Minireview.
Complex Virus-Host Interactions Involved in the Regulation of Classical Swine Fever Virus Replication: A Minireview.
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参与猪瘟病毒复制调节的复杂病毒-宿主相互作用：小型回顾
DOI：
10.3390/v9070171
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发表时间：
2017-07-05
期刊：
影响因子：
--
通讯作者：
Qiu HJ
中科院分区：
文献类型：
--
作者：
Li S;Wang J;Yang Q;Naveed Anwar M;Yu S;Qiu HJ
由猪瘟病毒（classical swine fever virus，CSFV）引起的猪瘟（classical swine fever，CSF）是世界上最严重的猪流行病之一。病毒是小的细胞内寄生物，因此依赖于细胞因子进行复制。CSFV-宿主相互作用的基本方面已经被很好地描述，例如有助于病毒附着的因素、基因组复制和翻译的调节、先天免疫的拮抗作用以及细胞凋亡的抑制。然而，那些参与病毒进入、组装和释放的宿主因子在很大程度上仍有待阐明。本文综述了猪瘟病毒生活史中病毒与宿主相互作用的最新研究进展，并分析了病毒进入、组装和释放的可能机制。最后，我们展望未来，并强调需要进一步了解的领域。
Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is one of the most devastating epizootic diseases of pigs in many countries. Viruses are small intracellular parasites and thus rely on the cellular factors for replication. Fundamental aspects of CSFV–host interactions have been well described, such as factors contributing to viral attachment, modulation of genomic replication and translation, antagonism of innate immunity, and inhibition of cell apoptosis. However, those host factors that participate in the viral entry, assembly, and release largely remain to be elucidated. In this review, we summarize recent progress in the virus–host interactions involved in the life cycle of CSFV and analyze the potential mechanisms of viral entry, assembly, and release. We conclude with future perspectives and highlight areas that require further understanding.
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