Thrombin-induced cerebral hemorrhage: role of protease-activated receptor-1.
Thrombin-induced cerebral hemorrhage: role of protease-activated receptor-1.
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DOI：
10.1007/s12975-013-0288-8
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发表时间：
2014-08
影响因子：
6.9
通讯作者：
Hua, Ya
中科院分区：
文献类型：
--
作者：
Cheng, Yingying;Xi, Guohua;Jin, Hang;Keep, Richard F.;Feng, Jiachun;Hua, Ya
凝血酶引起血脑屏障破坏，本研究检测凝血酶是否可通过蛋白酶激活受体-1（PAR-1）引起脑出血。雄性野生型和PAR-1敲除小鼠脑内注射凝血酶或生理盐水。然后对小鼠进行连续T2磁共振成像，并对小鼠实施安乐死以进行脑血红蛋白、铁和白细胞介素-1 β测量。凝血酶在野生型小鼠中引起大量T2病变和脑出血。这些作用在PAR-1敲除小鼠中显著降低。凝血酶还增加脑白细胞介素-1 β，这在PAR-1敲除小鼠中不存在。总之，凝血酶通过激活PAR-1增加白细胞介素-1 β水平并诱导脑出血。
Thrombin causes blood-brain barrier disruption and this study examined whether thrombin can cause brain hemorrhage through protease-activated receptor-1 (PAR-1). Male wild type and PAR-1 knockout mice had an intracerebral injection of thrombin or saline. Mice then underwent serial T2 magnetic resonance imaging and were euthanized for brain hemoglobin, iron and interleukin-1β measurements. Thrombin caused massive T2 lesions and brain hemorrhage in wild type mice. These effects were markedly reduced in PAR-1 knockout mice. Thrombin also increased brain interleukin-1β and this was absent in PAR-1 knockout mice. In conclusion, thrombin increases interleukin-1β levels and induces intracerebral hemorrhage through PAR-1 activation.
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影响因子：
8.3
作者：
Okauchi M;Hua Y;Keep RF;Morgenstern LB;Schallert T;Xi G
通讯作者：
Xi G
影响因子：
4.1
作者：
Masada, T;Hua, Y;Keep, RF
通讯作者：
Keep, RF
DOI：
10.1097/01.wcb.0000100062.36077.84
发表时间：
2004-02-01
影响因子：
6.3
作者：
Karabiyikoglu, M;Hua, Y;Xi, GH
通讯作者：
Xi, GH
影响因子：
8.3
作者：
Xue, Mengzhou;Hollenberg, Morley D.;Yong, V. Wee
通讯作者：
Yong, V. Wee
影响因子：
64.8
作者：
Coughlin, SR
通讯作者：
Coughlin, SR