Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex.
Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex.
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DOI：
10.1038/s41467-021-20943-9
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发表时间：
2021-02-09
影响因子：
16.6
通讯作者：
Averbeck BB
中科院分区：
文献类型：
--
作者：
Tang H;Bartolo R;Averbeck BB
前额叶皮层对于认知至关重要。尽管人们对前额皮质中认知变量的表示了解很多，但对认知操作背后的时空神经动力学知之甚少。在本研究中，我们检查了横向前额皮质（LPFC）的信息时序和流动，而猴子执行了双臂强盗强化学习任务，其中它们必须学会选择奖励动作或奖励对象。当我们独立分析 LPFC 子区域内的信号时，我们发现与所选对象和所选动作相关的信号强度和时间存在特定于任务的尾喙梯度。此外，当我们表征子区域之间的信息流时，我们发现从背侧到腹侧LPFC从动作到物体表征的信息流更强，而从腹侧到背侧LPFC从物体到动作表征的信息流更强。对象对动作的影响在对象块中更为明显，并且也反映了这些块中具体的学习。这些结果表明，LPFC 内存在解剖分离，随后信息快速整合。先前的研究对外侧前额叶皮层的功能组织提供了相互矛盾的证据。作者展示了沿着尾喙轴和背腹轴的特定任务信息流，反映了识别有价值物体的位置或身份的认知过程。
Prefrontal cortex is critical for cognition. Although much is known about the representation of cognitive variables in the prefrontal cortex, much less is known about the spatio-temporal neural dynamics that underlie cognitive operations. In the present study, we examined information timing and flow across the lateral prefrontal cortex (LPFC), while monkeys carried out a two-armed bandit reinforcement learning task in which they had to learn to select rewarding actions or rewarding objects. When we analyzed signals independently within subregions of the LPFC, we found a task-specific, caudo-rostral gradient in the strength and timing of signals related to chosen objects and chosen actions. In addition, when we characterized information flow among subregions, we found that information flow from action to object representations was stronger from the dorsal to ventral LPFC, and information flow from object to action representations was stronger from the ventral to dorsal LPFC. The object to action effects were more pronounced in object blocks, and also reflected learning specifically in these blocks. These results suggest anatomical segregation followed by the rapid integration of information within the LPFC. Previous studies provided conflicting evidence on the functional organization of the lateral prefrontal cortex. The authors show task-specific information flows along the caudo-rostral and dorso-ventral axes, reflecting the cognitive process of identifying the location or identity of a valuable object.
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影响因子：
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作者：
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