The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis.
The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis.
复制标题
粒细胞集落刺激因子对动物模型动脉粥样硬化进展的影响：荟萃分析
DOI：
10.1155/2017/6705363
复制
发表时间：
2017
影响因子：
--
通讯作者：
Pang L
中科院分区：
文献类型：
--
作者：
Liu M;Liu K;Chen D;Chen H;Sun K;Ju X;Lan J;Zhou Y;Wang W;Pang L
Background Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment. Methods We searched several databases and conducted a meta-analysis across seven articles using a random-effect model. All statistical analyses were performed using Review Manager Version 5.2 and Stata 12.0. Results We found that G-CSF therapy was associated with reduced atherosclerotic lesion area (weighted mean difference (WMD): 7.29%; 95% confidence interval (CI): 2.06–12.52%; P = 0.006). No significant differences in total serum cholesterol (P = 0.54) and triglyceride levels (P = 0.95) were noted in G-CSF treatment groups compared with controls. Multivariable metaregression analysis revealed that the animal type (rabbit, P = 0.022) and frequency of G-CSF administration (>20, P = 0.007) impacted the atherosclerotic lesion area changes. Conclusion The meta-analysis suggested that G-CSF treatment might inhibit the progression of atherosclerosis in animal models.
登录
查看更多内容
DOI：
10.1161/atvbaha.110.209296
发表时间：
2010-09-01
影响因子：
8.7
作者：
Ionita, Mihaela G.;van den Borne, Pleunie;de Kleijn, Dominique P. V.
通讯作者：
de Kleijn, Dominique P. V.
影响因子：
37.8
作者：
Haghighat, Amir;Weiss, Daiana;Taylor, W. Robert
通讯作者：
Taylor, W. Robert
影响因子：
5.7
作者：
Ince, H.;Valgimigli, M.;Nienaber, C. A.
通讯作者：
Nienaber, C. A.
影响因子：
5.5
作者：
Leclercq, Anne;Houard, Xavier;Michel, Jean-Baptiste
通讯作者：
Michel, Jean-Baptiste
影响因子：
5.4
作者：
Baumann, R;Yousefi, S;Simon, HU
通讯作者：
Simon, HU