Mice Exposed to Chronic Intermittent Hypoxia Simulate Clinical Features of Deficiency of both Qi and Yin Syndrome in Traditional Chinese Medicine.
Mice Exposed to Chronic Intermittent Hypoxia Simulate Clinical Features of Deficiency of both Qi and Yin Syndrome in Traditional Chinese Medicine.
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DOI：
10.1093/ecam/nep226
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Yu B
中科院分区：
文献类型：
--
作者：
Chai C;Kou J;Zhu D;Yan Y;Yu B
气阴两虚证（DQYS）是中医常见证候之一，主要表现为疲倦、消瘦、厌食、烦躁不安、心悸、脉快等。目前还没有能够反映该综合征临床特征的动物模型。本文根据DQYS的临床特点及一项关键病理因素，观察慢性间歇性缺氧小鼠6周的整体行为、体重、食量、运动活动及心电图的时程变化，最后测定出血时间。结果显示，间歇性缺氧一定时间后，小鼠出现毛发暗淡、无光泽、毛发暗淡、抵抗、攻击、体重减轻、摄食量减少、运动活动减少、心率加快、T波升高等症状，与DQYS的主要临床特征相似。同时还发现出血时间缩短，这与DQYS常伴有血瘀的临床事实一致。还根据现有文献概述了可能的解释。提示慢性间歇性缺氧可诱导符合DQYS临床特征的小鼠出现类似症状体征，为评价治疗该综合征的药物及进一步探讨该综合征与相关疾病的病理过程或相关性提供了合适的动物模型。
Deficiency of both Qi and Yin Syndrome (DQYS) is one of the common syndromes in traditional Chinese medicine (TCM), mainly characterized by tiredness, emaciation, anorexia, fidget, palpitation and rapid pulse, and so forth. Currently, there is no available animal model which can reflect the clinical features of this syndrome. In the present paper, we observed the time-course changes of whole behavior, body weight, food intake, locomotive activity and electrocardiogram in mice exposed to chronic intermittent hypoxia for 6 weeks, and measured bleeding time at last according to the clinical features of DQYS and one key pathological factor. The results showed that the mice exposed to intermittent hypoxia for certain time presented lackluster hair, dull looking hair, resistance, attacking, body weight loss, food intake decline, locomotive activity decrease, heart rate quickening and T wave elevating, which were similar to the major clinical features of DQYS. Meanwhile, bleeding time shortening was also found, which was consistent with the clinical fact that DQYS often accompanied with blood stasis. The possible explanation was also outlined according to the available literature. Such findings suggested chronic intermittent hypoxia could induce similar symptoms and signs in mice accorded with the clinical features of DQYS, which provided a suitable animal model for evaluation of drugs for the treatment of this syndrome and further exploration of pathological process or correlation of the syndrome and related diseases.
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影响因子：
158.5
作者：
EISENBERG, DM;KESSLER, RC;DELBANCO, TL
通讯作者：
DELBANCO, TL
DOI：
10.1016/j.devbrainres.2005.03.007
发表时间：
2005-06-09
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Mikati, MA;Zeinieh, MP;El Sabban, M
通讯作者：
El Sabban, M
影响因子：
4.8
作者：
Ambrosini, G;Nath, AK;Flores-Riveros, J
通讯作者：
Flores-Riveros, J
影响因子：
2.7
作者：
Kawaguchi, T;Tsubone, H;Kuwahara, M
通讯作者：
Kuwahara, M
影响因子：
7.5
作者：
Adams, M. J.;Irish, A. B.;Dogra, G. K.
通讯作者：
Dogra, G. K.