Pre-Operative Substance Use Disorder is Associated with Higher Risk of Long-Term Mortality Following Bariatric Surgery.
Pre-Operative Substance Use Disorder is Associated with Higher Risk of Long-Term Mortality Following Bariatric Surgery.
复制标题
术前药物使用障碍与减肥手术后长期死亡率较高的风险相关。
DOI：
10.1007/s11695-023-06564-9
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发表时间：
2023
期刊：
影响因子：
2.9
通讯作者：
Adams,Ted
中科院分区：
文献类型：
--
作者：
Kim,Jaewhan;Kelley,Joshua;Ikramuddin,Sayeed;Magel,Jake;Richards,Nathan;Adams,Ted
目的代谢和减肥手术（MBS）与降低全因死亡率有关。虽然MBS前患有物质使用障碍（SUD）的受试者数量已被记录，但术前SUD对MBS后长期死亡率的影响尚不清楚。本研究评估了长期死亡率的患者和术前SUD谁接受MBS.Materials and MethodsTwo全州范围内的数据库被用于本研究：犹他州减肥手术登记（UBSR）和犹他州人口数据库。在1997年至2018年期间接受MBS的受试者与死亡记录（1997-2021）相关联，以确定MBS后的任何死亡和死亡原因。所有死亡（内部、外部和未知原因）、内部死亡和外部死亡是研究的主要结局。死亡的外部原因包括受伤、中毒和自杀。内部死亡原因包括与自然原因相关的死亡，如心脏病，癌症和感染。共有17，215名患者被纳入分析。结果术前SUD患者的死亡风险是无SUD患者的2.47倍（HR = 2.47，p < 0.01）。术前有SUD者的内部死亡原因比无SUD者高129%（HR = 2.29，p < 0.01），外部死亡风险比术前无SUD者高216%结论术前SUD的全因、内因、接受减肥手术的患者的外部原因死亡率。图形摘要
PurposeMetabolic and bariatric surgery (MBS) has been associated with reduced all-cause mortality. While the number of subjects with substance use disorders (SUD) before MBS has been documented, the impact of pre-operative SUD on long-term mortality following MBS is unknown. This study assessed long-term mortality of patients with and without pre-operative SUD who underwent MBS.Materials and MethodsTwo statewide databases were used for this study: Utah Bariatric Surgery Registry (UBSR) and the Utah Population Database. Subjects who underwent MBS between 1997 and 2018 were linked to death records (1997–2021) to identify any death and cause for death following MBS. All deaths (internal, external, and unknown reasons), internal deaths, and external deaths were the primary outcomes of the study. External causes of death included death from injury, poisoning, and suicide. Internal causes of death included deaths that were associated with natural causes such as heart disease, cancer, and infections. A total of 17,215 patients were included in the analysis. Cox regression was used to estimate hazard ratios (HR) of controlled covariates, including the pre-operative SUD.ResultsThe subjects with pre-operative SUD had a 2.47 times higher risk of death as compared to those without SUD (HR = 2.47,p< 0.01). Those with pre-operative SUD had a higher internal cause of death than those without SUD by 129% (HR = 2.29,p< 0.01) and 216% higher external mortality risk than those without pre-operative SUD (HR = 3.16,p< 0.01).ConclusionPre-operative SUD was associated with higher hazards of all-cause, internal cause, and external cause mortality in patients who undergo bariatric surgery.Graphical Abstract
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