Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective.
Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective.
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谷氨酰胺诱导肠道分泌性免疫球蛋白 A 的分泌：机制视角
DOI：
10.3389/fimmu.2016.00503
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发表时间：
2016
影响因子：
7.3
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Ren W;Wang K;Yin J;Chen S;Liu G;Tan B;Wu G;Bazer FW;Peng Y;Yin Y
Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA. Altogether, the glutamine-intestinal SIgA axis has broad therapeutic implications for intestinal SIgA-associated diseases, such as celiac disease, allergies, and inflammatory bowel disease.
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影响因子：
6.3
作者：
Fuentes-Orozco, C;Anaya-Prado, R;Barrera-Zepeda, LM
通讯作者：
Barrera-Zepeda, LM
影响因子：
4.4
作者：
Fan, Jun;Meng, Qingyan;Ma, Liang
通讯作者：
Ma, Liang
影响因子：
3.5
作者：
Campos-Rodríguez R;Godínez-Victoria M;Abarca-Rojano E;Pacheco-Yépez J;Reyna-Garfias H;Barbosa-Cabrera RE;Drago-Serrano ME
通讯作者：
Drago-Serrano ME
影响因子：
32.4
作者：
Farache J;Koren I;Milo I;Gurevich I;Kim KW;Zigmond E;Furtado GC;Lira SA;Shakhar G
通讯作者：
Shakhar G
影响因子：
3.5
作者：
Chen, Shuai;Liu, Shuping;Wu, Guoyao
通讯作者：
Wu, Guoyao