Chaotic versus stochastic dynamics: a critical look at the evidence for nonlinear sequence dependent structure in dopamine neurons.

Chaotic versus stochastic dynamics: a critical look at the evidence for nonlinear sequence dependent structure in dopamine neurons.
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DOI:
10.1007/978-3-211-92660-4_9
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发表时间:
2009
影响因子:
--
通讯作者:
Shepard, P. D.
Shepard, P. D.
中科院分区:
其他
文献类型:
--
作者:
Canavier, C. C.;Shepard, P. D.

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中脑多巴胺神经元的放电模式被认为具有重要的行为后果。虽然这些神经元在体外被剥夺传入输入时有规律地放电,但它们在体内通常不规则地放电。目前尚不清楚这种不规则性在功能上是否重要,以及它是否源于多巴胺神经元的内在特性或网络相互作用。也不知道不规则的发射模式本质上是随机的还是确定的。区分与混沌相关的确定性非线性结构和包括相关噪声在内的其他结构源是一个固有的非平凡问题。在这里,我们解释了几何工具提供的非线性动力学领域和它们的应用程序的分析interspike间期(ISI)的数据从中脑多巴胺神经元。一项研究未能找到非线性决定论的有力证据,但其他研究已经确定了这种结构,并将其与网络相互作用联系起来。
The firing pattern of midbrain dopamine neurons is thought to have important behavioral consequences. Although these neurons fire regularly in vitro when deprived of their afferent inputs, they usually fire irregularly in vivo. It is not known whether the irregularity is functionally important, and whether it derives from intrinsic properties of dopamine neurons or network interactions. It is also not known whether the irregular firing pattern is fundamentally stochastic or deterministic in nature. Distinguishing between deterministic nonlinear structure associated with chaos and other sources of structure including correlated noise is an inherently nontrivial problem. Here we explain the geometric tools provided by the field of nonlinear dynamics and their application to the analysis of interspike interval (ISI) data from midbrain dopamine neurons. One study failed to find strong evidence of nonlinear determinism but others have identified such structure and correlated it with network interactions.
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