Adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV): a cross-sectional survey to measure in Lao PDR.
Adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV): a cross-sectional survey to measure in Lao PDR.
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DOI：
10.1186/1471-2458-13-617
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发表时间：
2013-06-28
影响因子：
4.5
通讯作者：
Schelp FP
中科院分区：
文献类型：
--
作者：
Hansana V;Sanchaisuriya P;Durham J;Sychareun V;Chaleunvong K;Boonyaleepun S;Schelp FP
自2001年以来，老挝人民民主共和国为艾滋病毒携带者提供了抗逆转录病毒疗法。抗逆转录病毒疗法有效性的一个关键因素是对个人福祉和公共健康都很好地遵守规定的养生法。依从性差可能会导致病毒耐药株的出现，并在危险行为期间传播。低收入国家环境中获得抗逆转录病毒治疗机会的增加促进了人们对在资源匮乏的情况下坚持治疗的兴趣。这项研究旨在调查老挝人民民主共和国艾滋病毒携带者中遵守抗逆转录病毒疗法的比例，并确定与不遵守抗逆转录病毒疗法有关的可能因素。2011年6月至11月，对艾滋病毒携带者在首都万象和萨凡纳赫特省医院的SetthaThirath医院接受免费抗逆转录病毒治疗的成年人进行了横断面研究。对346名艾滋病患者进行了匿名问卷调查。对依从率的估计是基于艾滋病病毒感染者提供的关于前三天药物摄入量的信息。采用Epidata 3.1和Stata 10.1统计软件进行数据分析。用常规统计方法计算各变量的频率和分布。双因素分析采用卡方检验、Mann-Whitney检验和Logistic回归分析。采用多元Logistic回归分析来确定不坚持抗逆转录病毒治疗的预测因素。P值<；0.05被认为具有统计学意义。在总共346名患者中，60%的人报告说超过95%的患者坚持接受抗逆转录病毒治疗。不按要求服药的原因是忙(97.0%)、健忘(62.2%)。在多因素分析中，中学文化程度(OR=3.7，95%CI：1.3~10.1，p=0.012)、非法吸毒(OR=16.1，95%CI：1.9~128.3，p=0.011)、不喜欢运动(OR=0.6，95%CI：0.4~0.9，p=0.028)、最近一个月忘记服用抗逆转录病毒药物(OR=2.3，95%CI：1.4~3.7，p=0.001)是不服药的独立危险因素。不坚持艺术与个人因素和接触艺术有关。增加对抗逆转录病毒药物治疗依从性的优先措施应着眼于加强咨询和综合干预，如指导艾滋病病毒感染者的药物自我管理技能，根据艾滋病病毒感染者的生活方式调整养生方案，以及改善依从性监测和卫生保健服务。
Since 2001, antiretroviral therapy (ART) for people living with HIV (PLHIV) has been available in the Lao People’s Democratic Republic (PDR). A key factor in the effectiveness of ART is good adherence to the prescribed regimen for both individual well-being and public health. Poor adherence can contribute to the emergence of drug resistant strains of the virus and transmission during risky behaviors. Increased access to ART in low-income country settings has contributed to an interest in treatment adherence in resource–poor contexts. This study aims to investigate the proportion of adherence to ART and identify possible factors related to non-adherence to ART among people living with HIV (PLHIV) in Lao PDR. A cross-sectional study was conducted with adults living with HIV receiving free ART at Setthathirath hospital in the capital Vientiane and Savannakhet provincial hospitals from June to November 2011. Three hundred and forty six PLHIV were interviewed using an anonymous questionnaire. The estimation of the adherence rate was based on the information provided by the PLHIV about the intake of medicine during the previous three days. The statistical software Epidata 3.1 and Stata 10.1 were used for data analysis. Frequencies and distribution of each variable were calculated by conventional statistical methods. The chi square test, Mann–Whitney test and logistic regression were used for bivariate analyses. Multiple logistic regression analysis was conducted to determine the predictors of non-adherence to ART. A p-value < 0.05 was considered to indicate statistical significance. Of a total of 346 patients, 60% reported more than 95% adherence to ART. Reasons for not taking medicine as required were being busy (97.0%), and being forgetful (62.2%). In the multivariate analysis, educational level at secondary school (OR=3.7, 95% CI:1.3-10.1, p=0.012); illicit drug use (OR=16.1, 95% CI:1.9-128.3, p=0.011); dislike exercise (OR=0.6, 95% CI:0.4-0.9, p=0.028), and forgetting to take ARV medicine during the last month (OR=2.3, 95% CI:1.4-3.7, p=0.001) were independently associated with non-adherence. Non-adherence to ART was associated with individual factors and exposure to ART. Priority measures to increase adherence to ART should aim to intensify counseling and comprehensive interventions, such as guidance for PLHIV on medication self-management skills, tailoring the regimen to the PLHIV life style, and improving adherence monitoring and health care services.
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DOI：
10.1097/01.qai.0000147522.34369.12
发表时间：
2005-04-01
影响因子：
3.6
作者：
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作者：
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Kissinger, P
DOI：
10.1080/09540120050042891
发表时间：
2000-06-01
影响因子：
1.7
作者：
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