Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes.
Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes.
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DOI：
10.1038/ncb1640
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发表时间：
2007-10
影响因子：
21.3
通讯作者：
Jones, Keith T.
中科院分区：
文献类型：
--
作者：
Reis, Alexandra;Madgwick, Suzanne;Chang, Heng-Yu;Nabti, Ibtissem;Levasseur, Mark;Jones, Keith T.
第一次女性减数分裂（MI）是唯一容易发生染色体分离错误，通过不分离，导致三体和早期妊娠丢失。在这里，我们显示了哺乳动物减数分裂的控制，这可能是这种易感性的根本区别。它涉及逆转的后期促进复合物（APC）的激活，其共激活剂cdc20和cdh 1的既定时间。APCcdh 1是活跃的第一，在前中期I，并需要为了允许同源congression，因为cdh 1的损失加快MI，导致过早的染色体分离和非分离表型。APCcdh 1靶向cdc20降解，但不靶向securin和cyclin B1。这些降解后，在MI通过APCcdc20，使cdc20重新合成成功的减数分裂进程所必需的。从APCcdh 1到APCcdc20活性的转换是通过增加CDK 1和cdh 1损失来控制的。这些发现表明，哺乳动物卵母细胞的第一次减数分裂的控制机制根本不同，在其他物种的减数分裂中没有观察到。
The first female meiotic division (MI) is uniquely prone to chromosome segregation errors through non-disjunction, resulting in trisomies and early pregnancy loss. Here, we show a fundamental difference in the control of mammalian meiosis which may underlie such susceptibility. It involved a reversal in the well-established timing of activation of the Anaphase-Promoting Complex (APC) by its co-activators cdc20 and cdh1. APCcdh1 was active first, during prometaphase I, and was needed in order to allow homologue congression, since loss of cdh1 speeded up MI, leading to premature chromosome segregation and a non-disjunction phenotype. APCcdh1 targeted cdc20 for degradation but not securin and cyclin B1. These were degraded later in MI through APCcdc20, making cdc20 re-synthesis essential for successful meiotic progression. The switch from APCcdh1 to APCcdc20 activity was controlled by increasing CDK1 and cdh1 loss. These findings demonstrate a fundamentally different mechanism of control for the first meiotic division in mammalian oocytes not observed in meioses of other species.
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影响因子：
64.8
作者：
Bashir, T;Dorrello, NV;Pagano, M
通讯作者：
Pagano, M
影响因子：
1.6
作者：
Salah, SM;Nasmyth, K
通讯作者：
Nasmyth, K
影响因子：
9.2
作者：
Vodermaier, HC;Gieffers, C;Peters, JM
通讯作者：
Peters, JM
影响因子：
7.8
作者：
Hagting, Anja;Den Elzen, Nicole;Vodermaier, Hartmut C;Waizenegger, Irene C;Peters, Jan-Michael;Pines, Jonathon
通讯作者：
Pines, Jonathon
DOI：
10.1083/jcb.200607070
发表时间：
2007-01-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Marangos P;Verschuren EW;Chen R;Jackson PK;Carroll J
通讯作者：
Carroll J