Bursopentin (BP5) protects dendritic cells from lipopolysaccharide-induced oxidative stress for immunosuppression.
Bursopentin (BP5) protects dendritic cells from lipopolysaccharide-induced oxidative stress for immunosuppression.
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Burspentin (BP5) 可保护树突状细胞免受脂多糖诱导的氧化应激，从而实现免疫抑制。
DOI：
10.1371/journal.pone.0117477
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Qin T;Yin Y;Yu Q;Yang Q
Dendritic cells (DCs) play a vital role in the regulation of immune-mediated inflammatory diseases. Thus, DCs have been regarded as a major target for the development of immunomodulators. However, oxidative stress could disturb inflammatory regulation in DCs. Here, we examined the effect of bursopentine (BP5), a novel pentapeptide isolated from chicken bursa of fabricius, on the protection of DCs against oxidative stress for immunosuppression. BP5 showed potent protective effects against the lipopolysaccharide (LPS)-induced oxidative stress in DCs, including nitric oxide, reactive oxygen species and lipid peroxidation. Furthermore, BP5 elevated the level of cellular reductive status through increasing the reduced glutathione (GSH) and the GSH/GSSG ratio. Concomitant with these, the activities of several antioxidative redox enzymes, including glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD), were obviously enhanced. BP5 also suppressed submucosal DC maturation in the LPS-stimulated intestinal epithelial cells (ECs)/DCs coculture system. Finally, we found that heme oxygenase 1 (HO-1) was remarkably upregulated by BP5 in the LPS-induced DCs, and played an important role in the suppression of oxidative stress and DC maturation. These results suggested that BP5 could protect the LPS-activated DCs against oxidative stress and have potential applications in DC-related inflammatory responses.
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影响因子：
--
作者：
Chen DY;Song PS;Hong JS;Chu CL;Pan IH;Chen YM;Lin CH;Lin SH;Lin CC
通讯作者：
Lin CC
影响因子：
4.1
作者：
Biswas, S.;Hwang, J. W.;Rahman, I.
通讯作者：
Rahman, I.
DOI：
10.1126/science.1183021
发表时间：
2010-01-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iwasaki A;Medzhitov R
通讯作者：
Medzhitov R
影响因子：
56.9
作者：
BRAND, A;GILMOUR, DG;GOLDSTEIN, G
通讯作者：
GOLDSTEIN, G
影响因子：
15.9
作者：
Hildeman, DA;Mitchell, T;Marrack, P
通讯作者：
Marrack, P