The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery.
The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery.
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DOI：
10.3389/fimmu.2018.01760
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发表时间：
2018
影响因子：
7.3
通讯作者：
Grabbe S
中科院分区：
文献类型：
--
作者：
Bros M;Nuhn L;Simon J;Moll L;Mailänder V;Landfester K;Grabbe S
纳米载体（NC）是非常有前途的癌症免疫治疗工具。尽管常规疫苗是基于以独立的方式施用抗原和佐剂，但纳米疫苗可以促进抗原和佐剂的细胞特异性共递送。此外，纳米疫苗可以在其表面上装饰有分子，这些分子有助于靶向特异性抗原递送到某些抗原呈递细胞类型或肿瘤细胞。然而，纳米疫苗的靶细胞特异性摄取高度依赖于纳米载体本身的修饰。其中之一是在体内给药后在NC周围形成蛋白质冠，这可能会有力地影响NC的细胞特异性靶向和摄取。因此，了解蛋白质冠的形成和组成对于在疫苗方法中使用纳米载体具有重要意义。这篇小综述将简要概述NC与体液或细胞表面的潜在非特异性相互作用，这些相互作用需要考虑用于癌症免疫治疗的NC疫苗的设计。
Nanocarriers (NC) are very promising tools for cancer immunotherapy. Whereas conventional vaccines are based on the administration of an antigen and an adjuvant in an independent fashion, nanovaccines can facilitate cell-specific co-delivery of antigen and adjuvant. Furthermore, nanovaccines can be decorated on their surface with molecules that facilitate target-specific antigen delivery to certain antigen-presenting cell types or tumor cells. However, the target cell-specific uptake of nanovaccines is highly dependent on the modifications of the nanocarrier itself. One of these is the formation of a protein corona around NC after in vivo administration, which may potently affect cell-specific targeting and uptake of the NC. Understanding the formation and composition of the protein corona is, therefore, of major importance for the use of nanocarriers in vaccine approaches. This Mini Review will give a short overview of potential non-specific interactions of NC with body fluids or cell surfaces that need to be considered for the design of NC vaccines for immunotherapy of cancer.
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影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
4.4
作者：
Burgdorf, Sven;Lukacs-Kornek, Veronika;Kurts, Christian
通讯作者：
Kurts, Christian
DOI：
10.1084/jem.192.12.1685
发表时间：
2000-12-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
den Haan JM;Lehar SM;Bevan MJ
通讯作者：
Bevan MJ
影响因子：
3.9
作者：
Chakraborti, Soumyananda;Joshi, Prachi;Chakrabarti, Pinak
通讯作者：
Chakrabarti, Pinak
影响因子：
16.1
作者：
Aggarwal P;Hall JB;McLeland CB;Dobrovolskaia MA;McNeil SE
通讯作者：
McNeil SE