Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association.
Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association.
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DOI：
10.1016/j.adaj.2017.08.045
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Carrasco-Labra A
中科院分区：
文献类型：
--
作者：
Lingen MW;Tampi MP;Urquhart O;Abt E;Agrawal N;Chaturvedi AK;Cohen E;D'Souza G;Gurenlian J;Kalmar JR;Kerr AR;Lambert PM;Patton LL;Sollecito TP;Truelove E;Banfield L;Carrasco-Labra A
Oral squamous cell carcinoma is the most common manifestation of malignancy in the oral cavity. Adjuncts are available for clinicians to evaluate lesions that seem potentially malignant. In this systematic review, the authors summarized the available evidence on patient-important outcomes, diagnostic test accuracy (DTA), and patients, values and preferences (PVPs) when using adjuncts for the evaluation of clinically evident lesions in the oral cavity. The authors searched for preexisting systematic reviews and assessed their quality using the Assessing the Methodological Quality of Systematic Reviews tool. The authors updated the selected reviews and searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify randomized controlled trials and DTA and PVPs studies. Pairs of reviewers independently conducted study selection, data extraction, and assessment of the certainty in the evidence by using the Grading of Recommendations Assessment, Development and Evaluation approach. The authors identified 4 existing reviews. DTA reviews included 37 studies. The authors retrieved 7,534 records, of which 9 DTA and 10 PVPs studies were eligible. Pooled sensitivity and specificity of adjuncts ranged from 0.39 to 0.96 for the evaluation of innocuous lesions and from 0.31 to 0.95 for the evaluation of suspicious lesions. Cytologic testing used in suspicious lesions appears to have the highest accuracy among adjuncts (sensitivity, 0.92; 95% confidence interval, 0.86 to 0.98; specificity, 0.94; 95% confidence interval, 0.88 to 0.99; low-quality evidence). Cytologic testing appears to be the most accurate adjunct among those included in this review. The main concerns are the high rate of false-positive results and serious issues of risk of bias and indirectness of the evidence. Clinicians should remain skeptical about the potential benefit of any adjunct in clinical practice.
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影响因子：
3.3
作者：
Awan, K. H.;Morgan, P. R.;Warnakulasuriya, S.
通讯作者：
Warnakulasuriya, S.
影响因子：
--
作者：
Chaudhari, Amit;Hegde-Shetiya, Sahana;Agrawal, Deepti
通讯作者：
Agrawal, Deepti
DOI：
10.1002/hed.21181
发表时间：
2010-03-01
影响因子：
2.9
作者：
Fingeret, Michelle Cororve;Vidrine, Damon J.;Gritz, Ellen R.
通讯作者：
Gritz, Ellen R.
DOI：
10.14219/jada.archive.1986.0007
发表时间：
1986-01-01
影响因子：
3.9
作者：
BOUQUOT, JE
通讯作者：
BOUQUOT, JE
影响因子：
2.5
作者：
Akl EA;Briel M;You JJ;Lamontagne F;Gangji A;Cukierman-Yaffe T;Alshurafa M;Sun X;Nerenberg KA;Johnston BC;Vera C;Mills EJ;Bassler D;Salazar A;Bhatnagar N;Busse JW;Khalid Z;Walter S;Cook DJ;Schünemann HJ;Altman DG;Guyatt GH
通讯作者：
Guyatt GH