Mediterranean diet and risk of rheumatoid arthritis: a population-based case-control study.
Mediterranean diet and risk of rheumatoid arthritis: a population-based case-control study.
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DOI：
10.1186/s13075-018-1680-2
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发表时间：
2018-08-09
影响因子：
4.9
通讯作者：
EIRA study group
中科院分区：
文献类型：
--
作者：
Johansson K;Askling J;Alfredsson L;Di Giuseppe D;EIRA study group
地中海饮食与较低的死亡率和较低的心血管疾病和癌症风险有关。尽管已经在几项研究中分析了地中海饮食的成分，但只有一项研究专门调查了地中海饮食与类风湿性关节炎(RA)风险之间的关联，并且没有报告存在关联。以人群为基础的病例对照研究瑞典类风湿性关节炎流行病学调查(EIRA)中1721例RA患者(病例)和3667例对照的资料进行了条件Logistic回归分析。地中海饮食得分从0到9，是根据124项食物频率调查问卷计算得出的。在Eira研究中(参与者的平均年龄53岁)，24.1%的患者和28.2%的对照组高度坚持地中海饮食(得分在6到9之间)。在对体重指数、教育水平、体力活动、膳食补充剂的使用、能量摄入和吸烟进行调整后，高依从性比低依从性(得分在0到2之间)降低了21%(OR 0.79；95%CI 0.65-0.96)患RA的几率。男性的OR值更低(OR0.49；95%CI为0.33~0.73)，而女性的OR值为0.94；95%CI为0.74~1.18。类风湿因子(RF)阳性(OR 0.69；95%CI 0.54-0.88)、RF阴性RA(OR 0.96；95%CI 0.68-1.34)和以瓜氨酸多肽(ACPA)抗体存在为特征的RA(ACPA阴性RA)的高饮食评分与低RA风险之间存在关联。在这项以人群为基础的大型病例对照研究中，地中海饮食评分与类风湿性关节炎风险呈负相关。然而，这种关联只在男性中被发现，并且只在血清阳性的RA中被发现。本文的在线版本(10.1186/s13075-018-1680-2)包含补充材料，可供授权用户使用。
The Mediterranean diet has been associated with lower mortality and lower risk of cardiovascular diseases and cancer. Although its components have been analysed in several studies, only one study has specifically investigated the association between Mediterranean diet and risk of rheumatoid arthritis (RA), and reported no association. Data on 1721 patients with incident RA (cases) and 3667 controls, matched on age, gender and residential area, from the Swedish epidemiological investigation of RA (EIRA), a population-based case-control study, were analysed using conditional logistic regression. The Mediterranean diet score, ranging from 0 to 9, was calculated from a 124-item food frequency questionnaire. In the EIRA study (median age of participants 53 years), 24.1% of the patients and 28.2% of the controls had high adherence to the Mediterranean diet (a score between 6 and 9). After adjustments for body mass index, educational level, physical activity, use of dietary supplements, energy intake, and smoking, high adherence reduced the odds of developing RA by 21% (OR 0.79; 95% CI 0.65–0.96) as compared to low adherence (a score between 0 and 2). The OR was even lower among men (OR 0.49; 95% CI 0.33–0.73), but no significant association was found among women (OR 0.94; 95% CI 0.74–1.18). An association between high diet score and low risk of RA was observed in rheumatoid factor (RF)-positive (OR 0.69; 95% CI 0.54–0.88), but not RF-negative RA (OR 0.96; 95% CI 0.68–1.34), and in RA characterised by presence of antibodies to citrullinated peptides (ACPA), but not in ACPA-negative RA. In this large population-based case-control study, the Mediterranean diet score was inversely associated with risk of RA. However, an association was only found among men and only in seropositive RA. The online version of this article (10.1186/s13075-018-1680-2) contains supplementary material, which is available to authorized users.
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