Prolactin induces adrenal hypertrophy.
Prolactin induces adrenal hypertrophy.
复制标题
催乳素诱发肾上腺肥大。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
J. Anselmo
中科院分区：
文献类型：
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作者：
E. J. Silva;L. Felicio;A. G. Nasello;M. ZAIDAN;J. Anselmo
虽然促肾上腺皮质激素通常被认为在肾上腺糖皮质激素分泌的调节中发挥主要作用，但一些报告表明其他垂体激素（例如催乳素）也在肾上腺功能的调节中发挥重要作用。本研究的目的是测量肾上腺皮质细胞面积，并确定从青春期前到青春期后的过渡对多潘立酮（4.0 mg kg-1 day-1，sc）诱导的高催乳素血症状态的影响。在高催乳素血症的成年和幼年大鼠中，尸检时测定的肾上腺比相应对照大鼠重：成年（30天：0.16+/-0.008和0.11+/-0.007；46天：0.17+/-0.006和0.12+/-0.008；61天：0.17+/-0.008）治疗动物和对照动物分别为0.008和0.10+/-0.004mg；P<0.05)，以及幼龄大鼠(30天：0.19+/-0.003和0.16+/-0.007，60天：0.16+/-0.006和0.13+/-0.009mg；P<0.05)。我们随机选择一个圆形区域，在其中计算肾上腺皮质细胞的细胞核。与对照组相比，高泌乳素血症成年大鼠和幼年大鼠的束状带细胞面积增加：成年大鼠：（治疗组和对照组动物分别为 61 天：524.90 +/- 47.85 和 244.84 +/- 9.03 microm2；P < 0.05），幼年大鼠：（15 天：462.30 +/- 16.24 和 414.28 +/- 18.19；60 天：640.51 +/- 12.91 和 480.24 +/- 22.79 微米；P < 0.05）。根据这些数据，我们得出结论，在高催乳素血症动物中观察到的肾上腺重量增加可能是由于催乳素诱导的肾上腺皮质细胞肥大所致。
Although adrenocorticotropic hormone is generally considered to play a major role in the regulation of adrenal glucocorticoid secretion, several reports have suggested that other pituitary hormones (e.g., prolactin) also play a significant role in the regulation of adrenal function. The aim of the present study was to measure the adrenocortical cell area and to determine the effects of the transition from the prepubertal to the postpubertal period on the hyperprolactinemic state induced by domperidone (4.0 mg kg-1 day-1, sc). In hyperprolactinemic adult and young rats, the adrenals were heavier, as determined at necropsy, than in the respective controls: adults (30 days: 0.16 +/- 0.008 and 0.11 +/- 0.007; 46 days: 0.17 +/- 0.006 and 0.12 +/- 0.008, and 61 days: 0.17 +/- 0.008 and 0.10 +/- 0.004 mg for treated and control animals, respectively; P < 0.05), and young rats (30 days: 0.19 +/- 0.003 and 0.16 +/- 0.007, and 60 days: 0.16 +/- 0.006 and 0.13 +/- 0.009 mg; P < 0.05). We selected randomly a circular area in which we counted the nuclei of adrenocortical cells. The area of zona fasciculata cells was increased in hyperprolactinemic adult and young rats compared to controls: adults: (61 days: 524.90 +/- 47.85 and 244.84 +/- 9.03 microm2 for treated and control animals, respectively; P < 0.05), and young rats: (15 days: 462.30 +/- 16.24 and 414.28 +/- 18.19; 60 days: 640.51 +/- 12.91 and 480.24 +/- 22.79 microm2 ; P < 0.05). Based on these data we conclude that the increase in adrenal weight observed in the hyperprolactinemic animals may be due to prolactin-induced adrenocortical cell hypertrophy.
雌激素诱导的高催乳素血症对成年雄性大鼠内分泌和性功能的影响。
影响因子：
4.1
作者：
Bartke,A;Doherty,PC;Steger,RW;Morgan,WW;Amador,AG;Herbert,DC;Siler-Khodr,TM;Smith,MS;Klemcke,HG;Hymer,WC
通讯作者：
Hymer,WC