Basal concentrations of oestradiol may predict the outcome of in-vitro maturation in regularly menstruating women.
Basal concentrations of oestradiol may predict the outcome of in-vitro maturation in regularly menstruating women.
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雌二醇的基础浓度可以预测定期月经女性的体外成熟结果。
DOI：
10.1093/humrep/16.5.862
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发表时间：
2001
影响因子：
6.1
通讯作者：
S. Lindenberg
中科院分区：
文献类型：
--
作者：
A. Mikkelsen;Anna;N. Skakkebaek;S. Lindenberg
回顾分析月经周期第3~4天，用血清FSH、雌二醇、抑制素B、抑制素A浓度和阴道超声观察卵泡数来预测月经周期中取卵数、成熟率和卵裂率的可行性。这项研究包括了100名因男性因素和/或输卵管因素而前往诊所的女性的132个连续的体外成熟愿望。移植83个周期，15个妊娠，每次抽吸妊娠率15/132(11%)，每次移植妊娠率15/83(18%)。第3天的FSH浓度和卵泡数可预测取卵的数量，但这些参数并不能预测随后的卵母细胞发育。抑制素B、抑制素A、雌二醇分别与卵母细胞数无相关性。雌二醇组(第1组，n=106个周期)的妊娠率显著高于雌二醇组(第2组，n=26个周期)(14个/次抽吸，P=0.03)。低雌二醇组按抑制素A浓度分组，1a组：低抑制素A组(阈值为10pg/ml，84个周期)，1b组：高抑制素A浓度组(>；或=10pg/ml，n=19)。1a组妊娠率(14/84，17%)明显高于1b组(0/19，0%)(P=0.03)。结论：低基础雌二醇浓度(200pmol/L)是预测IVM妊娠的有用因素。抑制素A的浓度为10pg/ml，具有一定的附加值。
Retrospectively it was examined whether the number of retrieved oocytes, the maturation rate and cleavage rate can be predicted in regularly menstruating women by the use of the following predictive variables on cycle day 3-4: the concentration of FSH, oestradiol, inhibin B and inhibin A in serum and and the number of ovarian follicles seen by vaginal ultrasound. The study included 132 consecutive aspirations in 100 women attending the clinic for in-vitro maturation due to male factor and/or tubal factor. Fifteen pregnancies were obtained after transfer in 83 cycles, giving a pregnancy rate of 15/132 (11%) per aspiration and 15/83 (18%) per transfer. The concentration of FSH and the number of follicles on day 3 predicted the number of oocytes retrieved, whereas these parameters did not predict the subsequent development of oocytes. No correlation was found between the inhibin B, inhibin A, oestradiol and the number of oocytes respectively. The group with a low concentration of oestradiol on cycle day 3 (threshold <200 pmol/l) (group 1, n = 106 cycles) had a significantly higher pregnancy rate compared to the group with a higher concentration (group 2, n = 26 cycles) (14 versus 0% per aspiration, P = 0.03). The group with a low concentration of oestradiol was subdivided according to the concentration of inhibin A. Group 1a: low inhibin A (threshold <10 pg/ml, n = 84 cycles) and group 1b: high inhibin A concentration (> or =10 pg/ml, n = 19). The pregnancy rate in group 1a (14/84, 17%) differed significantly from group 1b (0/19, 0%) (P = 0.03). It is concluded that a low basal concentration of oestradiol (<200 pmol/l) was shown to be a useful prognostic factor of pregnancy in IVM. The concentration of inhibin A (<10 pg/ml) was of added value.
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使用特定的双位点酶联免疫吸附测定，患有多囊卵巢综合征的男性和女性体内循环的二聚抑制素水平相对较低。
DOI：
10.1210/jcem.79.1.8027251
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Lambert-Messerlian,GM;Hall,JE;Sluss,PM;Taylor,AE;Martin,KA;Groome,NP;CrowleyJr,WF;Schneyer,AL
通讯作者：
Schneyer,AL
影响因子：
6.1
作者：
Hall, JE;Welt, CK;Cramer, DW
通讯作者：
Cramer, DW
全身雌二醇的过早升高会降低恒河猴的卵泡刺激激素的血清水平，并延长月经周期的卵泡期。
影响因子：
4.8
作者：
Zeleznik,AJ
通讯作者：
Zeleznik,AJ
抑制素 B 作为不孕女性卵巢储备的测试。
DOI：
10.1093/humrep/14.11.2818
发表时间：
1999
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Corson,SL;Gutmann,J;Batzer,FR;Wallace,H;Klein,N;Soules,MR
通讯作者：
Soules,MR