MEROPS: the peptidase database.
MEROPS: the peptidase database.
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Merops:肽酶数据库。
DOI:
10.1093/nar/gkj089
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发表时间:
2006-01-01
影响因子:
14.9
通讯作者:
Barrett, Alan J.
中科院分区:
文献类型:
--
作者:
Rawlings, Neil D.;Morton, Fraser R.;Barrett, Alan J.
Peptidases (proteolytic enzymes) and their natural, protein inhibitors are of great relevance to biology, medicine and biotechnology. The MEROPS database () aims to fulfil the need for an integrated source of information about these proteins. The organizational principle of the database is a hierarchical classification in which homologous sets of proteins of interest are grouped into families and the homologous families are grouped in clans. The most important addition to the database has been newly written, concise text annotations for each peptidase family. Other forms of information recently added include highlighting of active site residues (or the replacements that render some homologues inactive) in the sequence displays and BlastP search results, dynamically generated alignments and trees at the peptidase or inhibitor level, and a curated list of human and mouse homologues that have been experimentally characterized as active. A new way to display information at taxonomic levels higher than species has been devised. In the Literature pages, references have been flagged to draw attention to particularly ‘hot’ topics.
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影响因子:
10.7
作者:
SAITOU, N;NEI, M
通讯作者:
NEI, M
DOI:
10.1073/pnas.85.8.2444
发表时间:
1988-04-01
影响因子:
11.1
作者:
PEARSON, WR;LIPMAN, DJ
通讯作者:
LIPMAN, DJ
影响因子:
5.8
作者:
Howe, K;Bateman, A;Durbin, R
通讯作者:
Durbin, R
影响因子:
3
作者:
Edgar RC
通讯作者:
Edgar RC
影响因子:
5.6
作者:
ALTSCHUL, SF;GISH, W;LIPMAN, DJ
通讯作者:
LIPMAN, DJ