MEROPS: the peptidase database.

MEROPS: the peptidase database.
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Merops:肽酶数据库。

DOI:
10.1093/nar/gkj089
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发表时间:
2006-01-01
影响因子:
14.9
通讯作者:
Barrett, Alan J.
Barrett, Alan J.
中科院分区:
生物学2区
文献类型:
--
作者:
Rawlings, Neil D.;Morton, Fraser R.;Barrett, Alan J.

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肽酶(蛋白水解酶)及其天然的蛋白质抑制剂与生物学、医学和生物技术具有重要的相关性。MEROPS数据库()旨在满足对这些蛋白质的综合信息来源的需求。数据库的组织原则是分层分类,其中感兴趣的蛋白质的同源集合被分组为家族,并且同源家族被分组为氏族。最重要的除了数据库已被新写的,简洁的文本注释为每个肽酶家族。最近添加的其他形式的信息包括突出显示序列显示和BlastP搜索结果中的活性位点残基(或使某些同源物失活的替换),在肽酶或抑制剂水平上动态生成的比对和树,以及已被实验表征为活性的人类和小鼠同源物的策划列表。一种新的方法来显示信息的分类水平高于物种已经设计出来。在文献页面中,参考文献已被标记,以引起对特别“热门”主题的关注。
Peptidases (proteolytic enzymes) and their natural, protein inhibitors are of great relevance to biology, medicine and biotechnology. The MEROPS database () aims to fulfil the need for an integrated source of information about these proteins. The organizational principle of the database is a hierarchical classification in which homologous sets of proteins of interest are grouped into families and the homologous families are grouped in clans. The most important addition to the database has been newly written, concise text annotations for each peptidase family. Other forms of information recently added include highlighting of active site residues (or the replacements that render some homologues inactive) in the sequence displays and BlastP search results, dynamically generated alignments and trees at the peptidase or inhibitor level, and a curated list of human and mouse homologues that have been experimentally characterized as active. A new way to display information at taxonomic levels higher than species has been devised. In the Literature pages, references have been flagged to draw attention to particularly ‘hot’ topics.
DOI: 10.1093/oxfordjournals.molbev.a040454
发表时间: 1987-07-01
影响因子: 10.7
作者:
SAITOU, N;NEI, M
通讯作者: NEI, M
DOI: 10.1073/pnas.85.8.2444
发表时间: 1988-04-01
影响因子: 11.1
作者:
PEARSON, WR;LIPMAN, DJ
通讯作者: LIPMAN, DJ
DOI: 10.1093/bioinformatics/18.11.1546
发表时间: 2002-11-01
期刊: BIOINFORMATICS
影响因子: 5.8
作者:
Howe, K;Bateman, A;Durbin, R
通讯作者: Durbin, R
DOI: 10.1186/1471-2105-5-113
发表时间: 2004-08-19
期刊: BMC bioinformatics
影响因子: 3
作者:
Edgar RC
通讯作者: Edgar RC
DOI: 10.1016/s0022-2836(05)80360-2
发表时间: 1990-10-05
影响因子: 5.6
作者:
ALTSCHUL, SF;GISH, W;LIPMAN, DJ
通讯作者: LIPMAN, DJ