Potential negative effect of total parenteral nutrition on the human circadian clock
Potential negative effect of total parenteral nutrition on the human circadian clock
复制标题
全肠外营养对人体生物钟的潜在负面影响
DOI：
10.1111/gtc.12976
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发表时间：
2022
期刊：
影响因子：
2.1
通讯作者：
Akashi Makoto
中科院分区：
文献类型：
--
作者：
Tatsumoto Muneto;Matsumura Ritsuko;Endo Takuyuki;Tokuda Isao T.;Node Koichi;Akashi Makoto
当患者不能自己进食时，全肠外营养（TPN）是一种临床有益的维持营养的方法。然而，许多动物研究表明，昼夜节律受到进食时间的强烈影响，这引起了人们的担忧，即全天候连续TPN可能对患者的昼夜节律产生意外的负面影响。为了研究这一问题，我们使用毛囊细胞比较了有或没有TPN的老年受试者的时钟基因表达，发现虽然没有非TPN受试者显示外周时钟基因表达的昼夜节律有任何明显缺陷，但一部分接受连续TPN的老年受试者显示外周时钟的昼夜节律异常。因此，全天候连续TPN可能会扰乱外周昼夜节律，因此建议TPN需要考虑时间因素。
When patients cannot eat on their own, total parenteral nutrition (TPN) is a clinically beneficial method of maintaining nutrition. However, many animal studies have demonstrated that circadian rhythms are strongly affected by feeding time, raising the concern that continuous TPN around the clock may have an unexpected negative impact on the circadian clock of patients. To investigate this concern, we compared clock gene expression of aged subjects with or without TPN using hair follicle cells and found that while none of the non‐TPN subjects showed any obvious defects in circadian rhythms of peripheral clock gene expression, a portion of aged subjects receiving continuous TPN showed abnormal circadian rhythms in peripheral clocks. Continuous TPN around the clock may therefore potentially perturb peripheral circadian rhythms, giving rise to the proposal that TPN needs to be administered with consideration to time factors.
影响因子：
2.8
作者：
Kitamura, Shingo;Hida, Akiko;Mishima, Kazuo
通讯作者：
Mishima, Kazuo
影响因子：
18.2
作者：
Welsh DK;Takahashi JS;Kay SA
通讯作者：
Kay SA
影响因子：
56.9
作者：
Stokkan, KA;Yamazaki, S;Menaker, M
通讯作者：
Menaker, M