Mechanisms linking obesity and cancer.
Mechanisms linking obesity and cancer.
复制标题
DOI：
10.1016/j.bbalip.2013.02.008
复制
发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Nomura DK
中科院分区：
文献类型：
--
作者：
Louie SM;Roberts LS;Nomura DK
在过去的几十年里，美国成年人肥胖的发病率一直在稳步上升。许多与肥胖相关的合并症已经得到证实，如2型糖尿病和心血管疾病。然而，最近肥胖和各种癌症的流行之间的流行病学关系也被发现。围绕白色脂肪组织功能的范式从纯粹的能量储存组织转变为具有内分泌和代谢相关性的组织，已经导致涉及肥胖如何驱动癌症患病率和癌症死亡的几种机制。目前，这些机制分为四类-增加的脂质和脂质信号，炎症反应，胰岛素抵抗和脂肪因子。在这篇综述中，我们研究了这些类别中的每一个以及它们驱动癌症发病机制的机制。了解肥胖和癌症之间的关系，特别是这些级联中的控制节点，对于开发有效的治疗方法或干预措施来对抗这种致命的组合至关重要。
The incidence of obesity in US adults has been steadily increasing over the past few decades. Many comorbidities associated with obesity have been well-established such as type 2 diabetes and cardiovascular diseases. However, more recently an epidemiological relationship between obesity and the prevalence of a variety of cancers has also been uncovered. The shift of the paradigm surrounding white adipose tissue function from purely an energy storage tissue, to one that has both endocrine and metabolic relevance, has led to several mechanisms implicated in how obesity drives cancer prevalence and cancer deaths. Currently, there are four categories into which these mechanisms fall – increased lipids and lipid signaling, inflammatory responses, insulin resistance, and adipokines. In this review, we examine each of these categories and the mechanisms through which they drive cancer pathogenesis. Understanding the relationship(s) between obesity and cancer and especially the nodal points of control in these cascades will be essential in developing effective therapeutics or interventions for combating this deadly combination.
登录
查看更多内容
影响因子：
50.3
作者：
Calado DP;Zhang B;Srinivasan L;Sasaki Y;Seagal J;Unitt C;Rodig S;Kutok J;Tarakhovsky A;Schmidt-Supprian M;Rajewsky K
通讯作者：
Rajewsky K
影响因子：
56.9
作者：
Chan, JM;Stampfer, MJ;Pollak, M
通讯作者：
Pollak, M
影响因子：
7.1
作者：
Biro, Frank M.;Wien, Michelle
通讯作者：
Wien, Michelle
影响因子：
--
作者：
BONISCHNETZLER, M;SCHMID, C;FROESCH, ER
通讯作者：
FROESCH, ER
影响因子：
4.8
作者：
Catalano, S;Mauro, L;Andó, S
通讯作者：
Andó, S