Tight junctions: a barrier to the initiation and progression of breast cancer?
Tight junctions: a barrier to the initiation and progression of breast cancer?
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DOI：
10.1155/2010/460607
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发表时间：
2010
影响因子：
--
通讯作者：
Hopkins AM
中科院分区：
文献类型：
--
作者：
Brennan K;Offiah G;McSherry EA;Hopkins AM
乳腺癌是一种复杂的异质性疾病，它起源于乳腺导管和小叶的上皮细胞。相邻上皮细胞之间的正确粘附在确定上皮组织的正常结构和功能中是重要的，并且有越来越多的证据表明失调的细胞-细胞粘附与许多癌症相关。本文就紧密连接（TJ）这一细胞-细胞粘附复合体的研究进展作一综述，并对TJ参与乳腺癌发生、发展的最新证据进行总结。我们将首先概述TJ的蛋白质组成，并讨论TJ复合物的功能。其次，我们将研究这些功能的改变如何促进乳腺癌的发生或进展;通过重点关注TJ对细胞极性、细胞命运和细胞迁移的调节影响。最后，我们将概述TJ蛋白的药理学靶向可能有助于限制乳腺癌进展。总的来说，我们希望说明TJ改变和乳腺癌之间的关系是一个复杂的，但这一领域提供的承诺，揭示与乳腺癌进展的基本机制。
Breast cancer is a complex and heterogeneous disease that arises from epithelial cells lining the breast ducts and lobules. Correct adhesion between adjacent epithelial cells is important in determining the normal structure and function of epithelial tissues, and there is accumulating evidence that dysregulated cell-cell adhesion is associated with many cancers. This review will focus on one cell-cell adhesion complex, the tight junction (TJ), and summarize recent evidence that TJs may participate in breast cancer development or progression. We will first outline the protein composition of TJs and discuss the functions of the TJ complex. Secondly we will examine how alterations in these functions might facilitate breast cancer initiation or progression; by focussing on the regulatory influence of TJs on cell polarity, cell fate and cell migration. Finally we will outline how pharmacological targeting of TJ proteins may be useful in limiting breast cancer progression. Overall we hope to illustrate that the relationship between TJ alterations and breast cancer is a complex one; but that this area offers promise in uncovering fundamental mechanisms linked to breast cancer progression.
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影响因子：
11.4
作者：
Balda, MS;Matter, K
通讯作者：
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影响因子：
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作者：
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DOI：
10.1196/annals.1414.018
发表时间：
2008-01-01
期刊：
RECENT ADVANCES IN CLINICAL ONCOLOGY
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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