Pharmacological characterization of lower esophageal sphincter relaxation induced by swallowing, vagal efferent nerve stimulation, and esophageal distention.
Pharmacological characterization of lower esophageal sphincter relaxation induced by swallowing, vagal efferent nerve stimulation, and esophageal distention.
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吞咽、迷走传出神经刺激和食管扩张引起的下食管括约肌松弛的药理学特征。
DOI：
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发表时间：
1992
影响因子：
2.1
通讯作者：
N. Anand
中科院分区：
文献类型：
--
作者：
W. Paterson;M. Anderson;N. Anand
为了描述下食道括约肌松弛的神经通路，在存在和不存在可能的神经递质药理拮抗的情况下，在吞咽、迷走神经传出神经刺激和腔内球囊扩张的情况下，监测来自负鼠下食道括约肌的腔内压力。阿托品、六甲基铵和5-甲氧基二甲基色胺的联合应用，可显著拮抗吞咽和迷走神经刺激引起的LES松弛，但不影响球囊扩张引起的LES松弛。另一方面，给予一氧化氮合酶抑制剂N omega硝基-L-精氨酸甲酯，可显著抑制刺激迷走神经、吞咽和扩张球囊所引起的LES松弛，而给予一氧化氮合酶底物L-精氨酸可逆转这一作用。这些研究表明，扩张诱导的介导LES松弛的壁内通路不涉及神经节细胞的传递，类似于迷走抑制通路到LES的传导。然而，所有形式的刺激诱导的LES松弛似乎依赖于一氧化氮作为最终的介导物。
To characterize the neural pathways involved in lower esophageal sphincter relaxation, intraluminal pressures from the lower esophageal sphincter of the opossum were monitored during swallowing, vagal efferent nerve stimulation, and intraluminal balloon distention in the presence and absence of pharmacologic antagonism of putative neurotransmitters. The combination of atropine, hexamethonium, and 5-methoxydimethyltryptamine, which is known to block ganglionic transmission in the vagal inhibitory pathway to the lower esophageal sphincter, significantly antagonized LES relaxation induced by both swallowing and vagal stimulation, but did not affect the LES relaxation induced by balloon distention. Administration of the nitric oxide synthase inhibitor N omega nitro-L-arginine methyl ester, on the other hand, markedly inhibited LES relaxation induced by vagal stimulation, swallowing, and balloon distention, and this effect was reversed by administration of the nitric oxide synthase substrate L-arginine. These studies indicate that the distension-induced intramural pathway mediating LES relaxation does not involve ganglionic transmission similar to that of the vagal inhibitory pathway to the LES. However, the LES relaxation induced by all forms of stimuli appears to depend on nitric oxide as a final mediator.
DOI：
10.1073/pnas.84.24.9265
发表时间：
1987-12-01
影响因子：
11.1
作者：
IGNARRO, LJ;BUGA, GM;CHAUDHURI, G
通讯作者：
CHAUDHURI, G
DOI：
10.1152/ajpgi.1988.255.5.g587
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Paterson,WG;Rattan,S;Goyal,RK
通讯作者：
Goyal,RK
影响因子：
158.5
作者：
DODDS, WJ;DENT, J;EGIDE, MS
通讯作者：
EGIDE, MS