Motion Processing Deficits in Children With Cerebral Visual Impairment and Good Visual Acuity.
Motion Processing Deficits in Children With Cerebral Visual Impairment and Good Visual Acuity.
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具有脑视觉障碍和良好视力的儿童的运动处理缺陷。
DOI：
10.1167/iovs.62.14.12
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发表时间：
2021-11-01
影响因子：
4.4
通讯作者：
Norcia AM
中科院分区：
文献类型：
--
作者：
Chandna A;Nichiporuk N;Nicholas S;Kumar R;Norcia AM
我们试图使用客观、可量化的方法（稳态视觉诱发电位 [SSVEP]）来表征视力良好的脑视力障碍 (CVI) 儿童的神经运动处理缺陷。我们记录了对三种类型的视觉运动（绝对运动和更复杂的相对和旋转运动）的 SSVEP 响应，并将它们与形状相关的游标和轮廓响应进行比较。我们研究了 31 名通过详细临床检查诊断患有 CVI 的儿童和 28 名年龄匹配的健康对照者。通过在刺激频率的适当响应谐波下进行的测量，我们发现与健康对照组相比，CVI 儿童在相对和旋转运动的大脑处理方面存在显着缺陷，但在绝对运动方面却没有显着缺陷。与两组良好的识别敏锐度一致，游标敏锐度没有差异，轮廓相关的形状反应也没有差异。复杂运动的缺陷，但基本运动和形态相关信号的相对较少，表明患有 CVI 的儿童纹状体外视觉运动区域优先受到损害。事实上，这些优先损失发生在没有明显视力损失的情况下，这表明它们并不是视力下降的继发因素，而是 CVI 中的一个独立脆弱性。这些结果证实了父母和看护者关于患有 CVI 的儿童在执行涉及运动感知的任务时遇到困难的报告。
We sought to characterize neural motion processing deficits in children with cerebral visual impairment (CVI) who have good visual acuity using an objective, quantifiable method (steady-state visual evoked potentials [SSVEPs]). We recorded SSVEPs in response to three types of visual motion – absolute motion and more complex relative and rotary motion, comparing them to form-related vernier and contour responses. We studied a group of 31 children with CVI diagnosed via detailed clinical examinations and 28 age-matched healthy controls. Using measurements made at the appropriate response harmonics of the stimulation frequency, we found significant deficits in cerebral processing of relative and rotary motion but not of absolute motion in children with CVI compared with healthy controls. Vernier acuity, in keeping with good recognition acuity in both groups, was not different, nor were contour-related form responses. Deficits for complex motion but relative sparing of elementary motion and form-related signals suggests preferential damage to extra-striate visual motion areas in children with CVI. The fact that these preferential losses occur in the absence of significant acuity loss indicates that they are not secondary to reduced visual acuity, but rather are an independent vulnerability in CVI. These results corroborate parental and caregivers’ reports of difficulties with tasks that involve motion perception in children with CVI.
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影响因子：
2
作者：
Bosch, Danielle G. M.;Boonstra, F. Nienke;de Vries, Bert B. A.
通讯作者：
de Vries, Bert B. A.
影响因子：
1.9
作者：
Fazzi, Elisa;Signorini, Sabrina Giovanna;Bianchi, Paolo Emilio
通讯作者：
Bianchi, Paolo Emilio
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
1.5
作者：
Dykens, EM
通讯作者：
Dykens, EM
影响因子：
8
作者：
Bassan, Haim;Limperopoulos, Catherine;du Plessis, Adre J.
通讯作者：
du Plessis, Adre J.