Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.
复制标题
DOI：
10.1002/hep.25905
复制
发表时间：
2012-12
期刊：
影响因子：
13.5
通讯作者：
Huang, Wendong
中科院分区：
文献类型：
--
作者：
Zhang, Lisheng;Wang, Yan-Dong;Chen, Wei-Dong;Wang, Xichun;Lou, Guiyu;Liu, Nian;Lin, Min;Forman, Barry M.;Huang, Wendong
FXR是核受体超家族的成员，是主要的胆汁酸受体。我们先前表明，FXR是促进物理切除或肝损伤后的肝再生/修复所必需的。然而，FXR促进肝再生/修复的机制仍不清楚。在这里，我们表明，无论是70%的部分肝切除术或四氯化碳诱导的肝损伤后，肝FXR和精氨酸FXR有助于促进肝再生/修复。肝FXR，而不是肠FXR，是肝再生/修复过程中诱导肝脏Foxm 1b基因表达所必需的。相反，在肝损伤后，肠FXR被激活以诱导肠中的FGF 15表达。FGF 15的异位表达能够挽救精氨酸特异性FXR缺失小鼠中有缺陷的肝再生/修复。这些结果表明，除了肝FXR的细胞自主作用之外，肠中由FXR激活的内分泌FGF 15途径也参与促进肝再生/修复。
FXR is a member of the nuclear receptor superfamily and is the primary bile acid receptor. We previously showed that FXR was required for the promotion of liver regeneration/repair after physical resection or liver injury. However, the mechanism by which FXR promotes liver regeneration/repair is still unclear. Here we showed that both hepatic-FXR and intestine-FXR contributed to promoting liver regeneration/repair after either 70% partial hepatectomy or CCl4-induced liver injury. Hepatic FXR, but not intestine FXR, is required for the induction of Foxm1b gene expression in liver during liver regeneration/repair. In contrast, intestine FXR is activated to induce FGF15 expression in intestine after liver damage. Ectopic expression of FGF15 was able to rescue the defective liver regeneration/repair in intestine-specific FXR null mice. These results demonstrate that, in addition to the cell-autonomous effect of hepatic FXR, the endocrine FGF15 pathway activated by FXR in intestine also participates in the promotion of liver regeneration/repair.
登录
查看更多内容
影响因子：
29.4
作者：
Traub RJ;Tang B;Ji Y;Pandya S;Yfantis H;Sun Y
通讯作者：
Sun Y
影响因子：
3.3
作者：
Qiao, L;Studer, E;Dent, P
通讯作者：
Dent, P
影响因子：
3.9
作者：
Eloranta, JJ;Kullak-Ublick, GA
通讯作者：
Kullak-Ublick, GA
DOI：
10.1161/01.atv.0000195793.73118.b4
发表时间：
2006-02-01
影响因子：
8.7
作者：
Gutierrez, A;Ratliff, EP;Davis, RA
通讯作者：
Davis, RA
影响因子：
29.4
作者：
Modica, Salvatore;Petruzzelli, Michele;Moschetta, Antonio
通讯作者：
Moschetta, Antonio