High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
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DOI：
10.1002/jmv.22018
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发表时间：
2011-04
影响因子：
12.7
通讯作者：
Mustonen, Jukka T.
中科院分区：
文献类型：
--
作者：
Outinen, Tuula K.;Makela, Satu M.;Ala-Houhala, Ilpo O.;Huhtala, Heini S. A.;Hurme, Mikko;Libraty, Daniel H.;Oja, Simo S.;Porsti, Ilkka H.;Syrjanen, Jaana T.;Vaheri, Antti;Mustonen, Jukka T.
肾病综合征（NE）是一种由普马拉汉坦病毒引起的肾综合征出血热。NE的严重程度差异很大。本研究的目的是评估血清吲哚胺2，3-双加氧酶（IDO）活性是否与NE的严重程度相关。对前瞻性收集的102例急性血清学证实的NE患者进行了检查。入院后连续5天测量血清犬尿氨酸、色氨酸、肌酐、CRP和血细胞计数。计算反映IDO活性的犬尿氨酸与色氨酸（kyn/trp）比率。受试者工作特征（ROC）分析显示，kyn/trp最大比值>202 μmol/mmol时，检测血清肌酐最大值>250 μmol/L的敏感性为85%，特异性为75%。最大kyn/trp比值>202 μmol/mmol（高IDO水平）也与反映疾病严重程度和肾损害的其他参数相关。与kyn/trp比值≤202 μmol/mmol的患者相比，高IDO水平患者的最大血清肌酐（379 vs. 102 μmol/L，P < 0.001）、血浆C反应蛋白（104.1 vs. 72.1 mg/L，P = 0.029）和血白细胞值（11.9 vs. 9.0 × 109/L，P < 0.001）较高。他们的最小尿量也较低（1，100与1，900 ml/天，P < 0.001），住院时间较长（8与5天，P < 0.001）。总之，高血清IDO活性与NE中疾病严重程度和肾损害增加相关。
Nephropathia epidemica (NE) is a hemorrhagic fever with renal syndrome caused by Puumala hantavirus. The severity of NE varies greatly. The aim of the present study was to evaluate whether serum indoleamine 2,3-dioxygenase (IDO) activity is associated with the severity of NE. A prospectively collected cohort of 102 consecutive patients with acute serologically confirmed NE was examined. Serum kynurenine, tryptophan, creatinine, CRP, and blood cell count were measured for up to 5 consecutive days after admission. The kynurenine to tryptophan (kyn/trp) ratio reflecting IDO activity was calculated. A maximum kyn/trp ratio >202 μmol/mmol had a sensitivity of 85% and a specificity of 75% for detecting maximum serum creatinine values >250 μmol/L by receiver operating characteristic (ROC) analysis. A maximum kyn/trp ratio >202 μmol/mmol (high IDO level) was also associated with other parameters reflecting the severity of the disease and renal impairment. Patients with high IDO levels had higher maximum serum creatinine (379 vs. 102 μmol/L, P < 0.001), plasma C-reactive protein (104.1 vs. 72.1 mg/L, P = 0.029), and blood leukocyte values (11.9 vs. 9.0 × 109/L, P < 0.001) compared to patients with kyn/trp ratio ≤202 μmol/mmol. They also had lower minimum urinary output (1,100 vs. 1,900 ml/day, P < 0.001) and longer hospital stays (8 vs. 5 days, P < 0.001). In conclusion, high serum IDO activity was associated with increased disease severity and renal impairment in NE.
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影响因子：
3.1
作者：
Huttunen, Reetta;Syrjanen, Jaana;Hurme, Mikko
通讯作者：
Hurme, Mikko
影响因子：
4.4
作者：
Hwu, P;Du, MX;Young, HA
通讯作者：
Young, HA
影响因子：
6.6
作者：
Bellmann-Weiler, Rosa;Schroecksnadel, Katharina;Weiss, Guenter
通讯作者：
Weiss, Guenter
影响因子：
19.6
作者：
Mustonen, J;Partanen, J;Vaheri, A
通讯作者：
Vaheri, A
影响因子：
19.6
作者：
Brandacher, G.;Cakar, F.;Fuchs, D.
通讯作者：
Fuchs, D.