Beyond Warburg: LDHA activates RAC for tumour growth.
Beyond Warburg: LDHA activates RAC for tumour growth.
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DOI:
10.1038/s42255-022-00709-3
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发表时间:
2022-12
影响因子:
20.8
通讯作者:
Sasaki, Atsuo T.
中科院分区:
文献类型:
--
作者:
Osaka, Natsuski;Sasaki, Atsuo T.
The physiological role of aerobic glycolysis (also known as the Warburg effect), which is observed in many tumours, is still not fully understood. The finding that lactate dehydrogenase A (LDHA) activates RAC1 in breast cancer sheds new light on this persistently enigmatic aspect of cancer metabolism.
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