Expression of catenins and p120cas in melanocytic nevi and cutaneous melanoma: deficient alpha-catenin expression is associated with melanoma progression.
Expression of catenins and p120cas in melanocytic nevi and cutaneous melanoma: deficient alpha-catenin expression is associated with melanoma progression.
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连环蛋白和 p120cas 在黑素细胞痣和皮肤黑色素瘤中的表达：α-连环蛋白表达不足与黑色素瘤进展相关。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
P. Hersey
中科院分区：
文献类型：
--
作者：
X. D. Zhang;P. Hersey
E-钙粘蛋白介导的细胞间粘附由包括α-、β-和γ-连环蛋白和p120 cas的胞质蛋白家族调节。E-钙粘蛋白表达的变化被认为是黑色素瘤发展的早期事件。最近的研究也引起了人们对β-连环蛋白的过度表达及其在黑色素瘤中作为癌基因的可能间接作用的关注。鉴于这些研究，我们已经检查了细胞质蛋白质的表达在13个黑色素细胞痣，34个原发性皮肤黑色素瘤和20个转移性黑色素瘤。α-、γ-连环蛋白和p120 cas在黑色素细胞痣和黑色素瘤中不均匀表达，并且经常缺失，而β-连环蛋白表达在所有病变中观察到。α-，β-和γ-连环蛋白和p120 cas的表达模式的特点是不同强度的细胞质和膜免疫反应。这些蛋白在黑素细胞痣和原发性黑色素瘤中的表达无显著差异。相比之下，α-连环蛋白表达与肿瘤厚度之间存在负相关性，并且与原发性黑色素瘤的垂直生长期相比，α-连环蛋白在放射状生长期更频繁地表达。与34例原发灶中的6例相比，在20例转移灶中的10例中观察到α-连环蛋白表达的缺失，并且在原发灶中的表达比转移灶中更显著。这些结果表明，α-，β-和γ-连环蛋白和p120 cas表达的变化是常见的黑色素细胞痣和黑色素瘤，α-连环蛋白表达的损失与黑色素瘤的侵袭和转移。
E-cadherin mediated intercellular adhesion is regulated by a family of cytoplasmic proteins that include alpha-, beta- and gamma-catenin and p120cas. Changes in expression of E-cadherin are believed to be an early event in melanoma development. Recent studies have also drawn attention to the over-expression of beta-catenin and its possible indirect role as an oncogene in melanoma. In view of these studies, we have examined the expression of cytoplasmic proteins immunohistochemically in 13 melanocytic nevi, 34 primary cutaneous melanomas and 20 metastatic melanomas. alpha-, gamma-catenin and p120cas were heterogeneously expressed in melanocytic nevi and melanomas and were frequently absent, whereas beta-catenin expression was observed in all lesions. The pattern of expression of alpha-, beta- and gamma-catenin and p120cas was characterised by cytoplasmic and membranous immunoreactivity of varying intensity. No significant difference was found in expression of these proteins between melanocytic nevi and primary melanoma. In contrast, there was an inverse correlation between alpha-catenin expression and tumor thickness and alpha-catenin was more frequently expressed in radial compared to vertical growth phase in primary melanoma. Loss of alpha-catenin expression was observed in ten of 20 metastases compared to six of 34 primaries and the expression was more marked in primaries than in metastases. These results indicated that alterations in alpha-, beta- and gamma-catenin and p120cas expression were common in melanocytic nevi and melanomas, and that loss of alpha-catenin expression was associated with melanoma invasiveness and metastasis.
影响因子：
6.5
作者：
RODECK, U;MELBER, K;HERLYN, M
通讯作者：
HERLYN, M
人类正常黑色素细胞和黑色素瘤之间钙粘蛋白谱的变化。
DOI：
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发表时间：
1996
期刊：
The journal of investigative dermatology. Symposium proceedings
影响因子：
--
作者：
Hsu,MY;Wheelock,MJ;Johnson,KR;Herlyn,M
通讯作者：
Herlyn,M
影响因子：
56.9
作者：
SU, LK;VOGELSTEIN, B;KINZLER, KW
通讯作者：
KINZLER, KW