Physiological and brain activity after a combined cognitive behavioral treatment plus video game therapy for emotional regulation in bulimia nervosa: a case report.
Physiological and brain activity after a combined cognitive behavioral treatment plus video game therapy for emotional regulation in bulimia nervosa: a case report.
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DOI：
10.2196/jmir.3243
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发表时间：
2014-08-12
影响因子：
7.4
通讯作者：
Fernandez-Aranda F
中科院分区：
文献类型：
--
作者：
Fagundo AB;Via E;Sánchez I;Jiménez-Murcia S;Forcano L;Soriano-Mas C;Giner-Bartolomé C;Santamaría JJ;Ben-Moussa M;Konstantas D;Lam T;Lucas M;Nielsen J;Lems P;Cardoner N;Menchón JM;de la Torre R;Fernandez-Aranda F
PlayMancer是一款视频游戏，旨在通过训练来减少唤醒和改善决策和规划，从而增加情绪调节并减少一般冲动行为。我们之前已经证明了PlayMancer在减少神经性贪食症（BN）患者的冲动和改善情绪调节方面的有用性。然而，这些改善是否真的转化为大脑的变化仍不清楚。本案例研究的目的是报告一名患有BN的28岁西班牙女性，并检查电子游戏疗法（VGT）和认知行为疗法（CBT）联合治疗后生理变量和大脑活动的变化。每周举行10次自愿培训小组会议。记录焦虑、生理和冲动测量结果。在10周VGT/CBT联合治疗前后，患者在1.5-T磁共振扫描仪中进行扫描，使用两种范式：（1）情绪面部匹配任务，和（2）多源干扰任务（MSIT）。完成治疗后，观察到平均心率降低。功能性磁共振成像（fMRI）结果表明，治疗后反应时间沿着降低，且准确度较高。患者参与的区域通常在健康对照中活跃，尽管在联合治疗后活跃区域的簇扩展减少。这些结果表明，在BN中的VGT治疗后，情绪调节和冲动控制的整体改善，通过生理和神经变化来证明。这些有希望的结果表明，CBT和VGT的联合治疗可能会导致功能性大脑变化，最终转化为更好的认知和情感表现。
PlayMancer is a video game designed to increase emotional regulation and reduce general impulsive behaviors, by training to decrease arousal and improve decision-making and planning. We have previously demonstrated the usefulness of PlayMancer in reducing impulsivity and improving emotional regulation in bulimia nervosa (BN) patients. However, whether these improvements are actually translated into brain changes remains unclear. The aim of this case study was to report on a 28-year-old Spanish woman with BN, and to examine changes in physiological variables and brain activity after a combined treatment of video game therapy (VGT) and cognitive behavioral therapy (CBT). Ten VGT sessions were carried out on a weekly basis. Anxiety, physiological, and impulsivity measurements were recorded. The patient was scanned in a 1.5-T magnetic resonance scanner, prior to and after the 10-week VGT/CBT combined treatment, using two paradigms: (1) an emotional face-matching task, and (2) a multi-source interference task (MSIT). Upon completing the treatment, a decrease in average heart rate was observed. The functional magnetic resonance imaging (fMRI) results indicated a post-treatment reduction in reaction time along with high accuracy. The patient engaged areas typically active in healthy controls, although the cluster extension of the active areas decreased after the combined treatment. These results suggest a global improvement in emotional regulation and impulsivity control after the VGT therapy in BN, demonstrated by both physiological and neural changes. These promising results suggest that a combined treatment of CBT and VGT might lead to functional cerebral changes that ultimately translate into better cognitive and emotional performances.
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影响因子：
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作者：
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